Last reviewed · How we verify
Tisseel Fibrin Sealant
Tisseel is a fibrin sealant that mimics the final step of the coagulation cascade to form a stable clot and seal tissue surfaces.
Tisseel is a fibrin sealant that mimics the final step of the coagulation cascade to form a stable clot and seal tissue surfaces. Used for Hemostasis and tissue sealing in general surgery, Hemostasis in cardiac surgery, Hemostasis in vascular surgery.
At a glance
| Generic name | Tisseel Fibrin Sealant |
|---|---|
| Sponsor | Massachusetts General Hospital |
| Drug class | Fibrin sealant |
| Target | Fibrinogen (substrate for thrombin-catalyzed polymerization) |
| Modality | Small molecule |
| Therapeutic area | Surgery/Hemostasis |
| Phase | FDA-approved |
Mechanism of action
Tisseel consists of two components—fibrinogen and thrombin—that when mixed together polymerize fibrinogen into fibrin, creating a biological adhesive that seals wounds and surgical sites. This mimics the natural hemostatic process and provides both hemostasis and tissue adhesion without requiring sutures or staples in many applications.
Approved indications
- Hemostasis and tissue sealing in general surgery
- Hemostasis in cardiac surgery
- Hemostasis in vascular surgery
- Hemostasis in neurosurgery
- Tissue adhesion in various surgical applications
Common side effects
- Allergic reaction
- Infection at application site
- Thrombosis (rare)
Key clinical trials
- Comparing Clinical Outcomes of the One-step Cartilage Transplantation in Cartilage Defects of the Knee With Conservative Treatment (PHASE3)
- A Trial of Intraoperative Fibrin Sealant on Postoperative Recovery After Total Knee Replacement (PHASE4)
- GATT-Patch Versus TachoSil in Liver Surgery (NA)
- Cost Effectiveness in Alveolar Bone Grafting in Patients With Cleft Lip and Palate (PHASE4)
- Clinical Study of Chondro-Gide® for Large Chondral Lesions in the Knee (NA)
- A Study of REcycled CartiLage Auto/Allo IMplantation to Treat and Repair Focal Hip Cartilage Defects (PHASE1)
- High-Purity Type I Collagen Nerve Wrapping in Peripheral Nerve Procedures: A Prospective Registry (NA)
- Phase 2a Multi-Center Prospective, Randomized Trial to Evaluate the Safety & Efficacy of Topical PEP-TISSEEL for Diabetic Foot Ulcers (DFU) (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Tisseel Fibrin Sealant CI brief — competitive landscape report
- Tisseel Fibrin Sealant updates RSS · CI watch RSS
- Massachusetts General Hospital portfolio CI