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Fibrin Sealant (Artiss)
Fibrin Sealant (Artiss) forms a fibrin clot by combining thrombin and fibrinogen to achieve hemostasis and tissue adhesion.
Fibrin Sealant (Artiss) forms a fibrin clot by combining thrombin and fibrinogen to achieve hemostasis and tissue adhesion. Used for Hemostasis and tissue adhesion during surgery, Bleeding control in cardiovascular, general, and orthopedic surgical procedures.
At a glance
| Generic name | Fibrin Sealant (Artiss) |
|---|---|
| Sponsor | Nguyen, Davis B., M.D. |
| Drug class | Fibrin sealant |
| Target | Fibrinogen; thrombin substrate |
| Modality | Small molecule |
| Therapeutic area | Surgery/Hemostasis |
| Phase | FDA-approved |
Mechanism of action
Artiss is a two-component fibrin sealant that mimics the final stages of the coagulation cascade. When thrombin and fibrinogen components are mixed, thrombin enzymatically converts fibrinogen to fibrin monomers, which polymerize to form a stable clot. This creates both hemostatic and adhesive properties, allowing it to seal tissues and control bleeding during surgical procedures.
Approved indications
- Hemostasis and tissue adhesion during surgery
- Bleeding control in cardiovascular, general, and orthopedic surgical procedures
Common side effects
- Allergic reaction
- Thromboembolism
- Infection at application site
Key clinical trials
- ARTISS a Single-centre Randomised Control Study (PHASE4)
- A Study Evaluating the Efficacy and Safety of ARTISS Human Fibrin Sealant as Used in External Rhinoplasty (PHASE2)
- Efficacy and Safety of ARTISS for Flap Adherence in Abdominoplasty (PHASE2)
- Safety and Efficacy Study of FS 4 IU VH S/D (Fibrin Sealant With 4IU/mL Thrombin, Vapor Heated, Solvent/Detergent Treated) to Adhere Split Thickness Skin Grafts and Improve Wound Healing in Burn Patients (PHASE3)
- Efficacy and Safety of FS VH S/D 4 S-apr for Flap Adherence in Rhytidectomy (PHASE3)
- Efficacy and Safety of Fibrin Sealant (FS) VH S/D-APR for Hemostasis and Wound Healing in Endoscopic Browlift
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Fibrin Sealant (Artiss) CI brief — competitive landscape report
- Fibrin Sealant (Artiss) updates RSS · CI watch RSS
- Nguyen, Davis B., M.D. portfolio CI