{"id":"fibrin-sealant-artiss","safety":{"commonSideEffects":[{"rate":null,"effect":"Allergic reaction"},{"rate":null,"effect":"Thromboembolism"},{"rate":null,"effect":"Infection at application site"}]},"_chembl":null,"_dailymed":{"setId":"92fc93e1-9695-4705-90c5-4452a80bb074","title":"ARTISS FIBRIN SEALANT (FIBRINOGEN HUMAN, HUMAN THROMBIN) SOLUTION [BAXTER HEALTHCARE CORPORATION]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Artiss is a two-component fibrin sealant that mimics the final stages of the coagulation cascade. When thrombin and fibrinogen components are mixed, thrombin enzymatically converts fibrinogen to fibrin monomers, which polymerize to form a stable clot. This creates both hemostatic and adhesive properties, allowing it to seal tissues and control bleeding during surgical procedures.","oneSentence":"Fibrin Sealant (Artiss) forms a fibrin clot by combining thrombin and fibrinogen to achieve hemostasis and tissue adhesion.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T04:00:21.089Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Hemostasis and tissue adhesion during surgery"},{"name":"Bleeding control in cardiovascular, general, and orthopedic surgical procedures"}]},"trialDetails":[{"nctId":"NCT04931615","phase":"PHASE4","title":"ARTISS a Single-centre Randomised Control Study","status":"COMPLETED","sponsor":"Mid and South Essex NHS Foundation Trust","startDate":"2022-02-01","conditions":"Breast Neoplasms, Mammaplasty","enrollment":135},{"nctId":"NCT01684020","phase":"PHASE2","title":"A Study Evaluating the Efficacy and Safety of ARTISS Human Fibrin Sealant as Used in External Rhinoplasty","status":"COMPLETED","sponsor":"DeNova Research","startDate":"2012-11-28","conditions":"Subjects Requesting and Requiring an Open Rhinoplasty","enrollment":10},{"nctId":"NCT01112735","phase":"PHASE2","title":"Efficacy and Safety of ARTISS for Flap Adherence in Abdominoplasty","status":"COMPLETED","sponsor":"Baxter Healthcare Corporation","startDate":"2010-05","conditions":"Seroma, Hematoma","enrollment":40},{"nctId":"NCT00157131","phase":"PHASE3","title":"Safety and Efficacy Study of FS 4 IU VH S/D (Fibrin Sealant With 4IU/mL Thrombin, Vapor Heated, Solvent/Detergent Treated) to Adhere Split Thickness Skin Grafts and Improve Wound Healing in Burn Patients","status":"COMPLETED","sponsor":"Baxter Healthcare Corporation","startDate":"2004-06","conditions":"Deep Partial or Full Thickness Wounds","enrollment":150},{"nctId":"NCT00999141","phase":"PHASE3","title":"Efficacy and Safety of FS VH S/D 4 S-apr for Flap Adherence in Rhytidectomy","status":"COMPLETED","sponsor":"Baxter Healthcare Corporation","startDate":"2009-09","conditions":"Face-lift, Facial Rhytidectomy","enrollment":75},{"nctId":"NCT01320514","phase":"","title":"Efficacy and Safety of Fibrin Sealant (FS) VH S/D-APR for Hemostasis and Wound Healing in Endoscopic Browlift","status":"UNKNOWN","sponsor":"Nguyen, Davis B., M.D.","startDate":"2010-12","conditions":"Compare Ecchymosis and Edema for Fibrin Sealant and no Fibrin Sealant","enrollment":10}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":36,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Fibrin Sealant (Artiss)","genericName":"Fibrin Sealant (Artiss)","companyName":"Nguyen, Davis B., M.D.","companyId":"nguyen-davis-b-m-d","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Fibrin Sealant (Artiss) forms a fibrin clot by combining thrombin and fibrinogen to achieve hemostasis and tissue adhesion. Used for Hemostasis and tissue adhesion during surgery, Bleeding control in cardiovascular, general, and orthopedic surgical procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}