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TISSEEL VH fibrin sealant
TISSEEL VH fibrin sealant is a Fibrin sealant Small molecule drug developed by Baxter Healthcare Corporation. It is currently in Phase 3 development for Hemostasis and tissue sealing during surgical procedures, Control of bleeding in cardiovascular, general, and orthopedic surgery.
TISSEEL VH is a fibrin sealant that mimics the final step of the coagulation cascade to form a stable fibrin clot for hemostasis and tissue sealing.
TISSEEL VH is a fibrin sealant that mimics the final step of the coagulation cascade to form a stable fibrin clot for hemostasis and tissue sealing. Used for Hemostasis and tissue sealing during surgical procedures, Control of bleeding in cardiovascular, general, and orthopedic surgery.
At a glance
| Generic name | TISSEEL VH fibrin sealant |
|---|---|
| Sponsor | Baxter Healthcare Corporation |
| Drug class | Fibrin sealant |
| Target | Fibrinogen; Thrombin substrate |
| Modality | Small molecule |
| Therapeutic area | Surgery/Hemostasis |
| Phase | Phase 3 |
Mechanism of action
TISSEEL VH consists of two components—human fibrinogen and human thrombin—that when combined activate the coagulation cascade to produce fibrin monomers, which polymerize into a stable clot. This provides both hemostatic control and tissue adhesion properties. The product is used topically during surgery to seal tissues, control bleeding, and promote wound healing.
Approved indications
- Hemostasis and tissue sealing during surgical procedures
- Control of bleeding in cardiovascular, general, and orthopedic surgery
Common side effects
- Infection at surgical site
- Hematoma formation
- Seroma
- Allergic reaction
Key clinical trials
- Comparing Clinical Outcomes of the One-step Cartilage Transplantation in Cartilage Defects of the Knee With Conservative Treatment (PHASE3)
- Phase 2a Multi-Center Prospective, Randomized Trial to Evaluate the Safety & Efficacy of Topical PEP-TISSEEL for Diabetic Foot Ulcers (DFU) (PHASE2)
- Adipose-Derived Stromal Cells (ASC's) for Pressure Ulcers (PHASE1)
- Fibroblast Growth Factor Regeneration of Tympanic Membrane Perforations (PHASE2)
- NoSeal Trial: Comparing Sealants Versus No Sealant for Preventing CSF Leak After Endonasal Skull Base Surgery (NA)
- Study to Evaluate the Safety, Tolerability, and Efficacy of PEP-TISSEEL in Subjects With Chronic Radiation Ulcer (PHASE1, PHASE2)
- Regeneration of Knee and Ankle Cartilage From Autologous Cartilage Mini-grafts (From the Patient's Own Cells) (PHASE1)
- Implantation of Cartilage Mini-grafts Made From Donor Cells to Treat Chondral Lesions of the Knee (PHASE1, PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- TISSEEL VH fibrin sealant CI brief — competitive landscape report
- TISSEEL VH fibrin sealant updates RSS · CI watch RSS
- Baxter Healthcare Corporation portfolio CI
Frequently asked questions about TISSEEL VH fibrin sealant
What is TISSEEL VH fibrin sealant?
How does TISSEEL VH fibrin sealant work?
What is TISSEEL VH fibrin sealant used for?
Who makes TISSEEL VH fibrin sealant?
What drug class is TISSEEL VH fibrin sealant in?
What development phase is TISSEEL VH fibrin sealant in?
What are the side effects of TISSEEL VH fibrin sealant?
What does TISSEEL VH fibrin sealant target?
Related
- Drug class: All Fibrin sealant drugs
- Target: All drugs targeting Fibrinogen; Thrombin substrate
- Manufacturer: Baxter Healthcare Corporation — full pipeline
- Therapeutic area: All drugs in Surgery/Hemostasis
- Indication: Drugs for Hemostasis and tissue sealing during surgical procedures
- Indication: Drugs for Control of bleeding in cardiovascular, general, and orthopedic surgery
- Compare: TISSEEL VH fibrin sealant vs similar drugs
- Pricing: TISSEEL VH fibrin sealant cost, discount & access