Endothelin receptor antagonist

This page covers all Endothelin receptor antagonist drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Endothelin receptor A (ETA) and Endothelin receptor B (ETB), Endothelin-1 receptor, Endothelin receptor (ETA/ETB).

Targets

Endothelin receptor A (ETA) and Endothelin receptor B (ETB) · Endothelin-1 receptor · Endothelin receptor (ETA/ETB) · ETA and ETB receptors · ET-A and ET-B receptors · Endothelin receptor

Marketed (2)

• Tracleer® · Actelion · Cardiovascular
  Tracleer blocks endothelin-1 receptors on vascular smooth muscle cells, preventing vasoconstriction and reducing pulmonary vascular resistance.
• Tracleer · AstraZeneca · Immunology

Phase 3 pipeline (4)

• ERA as specific PAH treatment · Eli Lilly and Company · Cardiovascular
  Endothelin receptor antagonists (ERAs) block endothelin-1 signaling in pulmonary vasculature to reduce vasoconstriction and improve hemodynamics in pulmonary arterial hypertension.
• SCH-58235 · National Heart, Lung, and Blood Institute (NHLBI) · Cardiovascular
  SCH-58235 is a selective endothelin receptor antagonist that blocks endothelin-1 signaling to reduce pulmonary vascular resistance and improve hemodynamics in pulmonary hypertension.
• macitentan (ACT-064992) · Actelion · Cardiovascular
  Macitentan is a dual endothelin receptor antagonist that blocks both ETA and ETB receptors to reduce pulmonary vascular resistance and improve exercise capacity in pulmonary arterial hypertension.
• Macitentan Tablets · Dr Sudarshan Rajagopal · Cardiovascular
  Macitentan is a dual endothelin receptor antagonist that blocks both ETA and ETB receptors to reduce pulmonary vascular resistance and improve exercise capacity in pulmonary arterial hypertension.

Phase 2 pipeline (5)

• ACT-128800 · Actelion · Cardiovascular
  ACT-128800 is an endothelin receptor antagonist that blocks the action of endothelin-1, a potent vasoconstrictor.
• Atrasentan high dose group · AbbVie (prior sponsor, Abbott) · Cardiovascular
  Atrasentan is an endothelin receptor antagonist that blocks the action of endothelin-1, a potent vasoconstrictor.
• Atrasentan low dose group · AbbVie (prior sponsor, Abbott) · Cardiovascular
  Endothelin receptor antagonist
• Assigned pulmonary hypertension medication · Bayer · Cardiovascular
  This drug works by inhibiting the action of endothelin-1, a potent vasoconstrictor.
• Bosentan group · Elpen Pharmaceutical Co. Inc. · Cardiovascular
  Bosentan is an endothelin receptor antagonist that works by blocking the action of endothelin-1, a potent vasoconstrictor.