ETA and ETB receptors — Drug Target

All drugs that target ETA and ETB receptors — marketed and clinical-stage. Includes 2 drug classes acting on this target.

Drug classes

Endothelin receptor antagonist · Dual endothelin receptor antagonist

Phase 3 pipeline (3)

• macitentan (ACT-064992) · Actelion · Endothelin receptor antagonist · Cardiovascular
  Macitentan is a dual endothelin receptor antagonist that blocks both ETA and ETB receptors to reduce pulmonary vascular resistance and improve exercise capacity in pulmonary arterial hypertension.
• Macitentan Tablets · Dr Sudarshan Rajagopal · Endothelin receptor antagonist · Cardiovascular
  Macitentan is a dual endothelin receptor antagonist that blocks both ETA and ETB receptors to reduce pulmonary vascular resistance and improve exercise capacity in pulmonary arterial hypertension.
• Macitentan Group · University of Giessen · Dual endothelin receptor antagonist · Cardiovascular
  Macitentan is a dual endothelin receptor antagonist that blocks both ETA and ETB receptors to reduce pulmonary vascular resistance and improve exercise capacity in pulmonary arterial hypertension.