What are Antiparasitic agent drugs?

Antiparasitic agent drugs are pharmacologic agents that share a common mechanism (typically targeting Glutamate-gated chloride channels (invertebrate-specific)). 4 are currently marketed, with 4 more in clinical development.

What are the marketed Antiparasitic agent drugs?

Marketed Antiparasitic agent drugs include Ivermectin 1% cream (IVM), Atovaquone Oral Suspension, Antimoniate of N-methylglucamine, Ivermectin 1% cream.

Antiparasitic agent

4 marketed 4 in Phase 3

This page covers all Antiparasitic agent drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Glutamate-gated chloride channels (invertebrate-specific), Cytochrome bc1 complex (Complex III), Leishmania glycolytic enzymes and mitochondrial function.

Targets

Glutamate-gated chloride channels (invertebrate-specific) · Cytochrome bc1 complex (Complex III) · Leishmania glycolytic enzymes and mitochondrial function · Glutamate-gated chloride channels · Glutamate-gated chloride channels (GluCl) · Leishmania glycolytic enzymes; reactive oxygen species generation

Marketed (4)

Ivermectin 1% cream (IVM) · Galderma R&D · Dermatology
Ivermectin binds to glutamate-gated chloride channels in parasites and arthropods, causing paralysis and death of the organisms.
Atovaquone Oral Suspension · University of Oxford · Infectious Disease
Atovaquone inhibits the cytochrome bc1 complex in the mitochondrial electron transport chain of parasites, disrupting energy production and causing parasite death.
Antimoniate of N-methylglucamine · University of Brasilia · Infectious Disease
Antimoniate of N-methylglucamine is a pentavalent antimony compound that kills Leishmania parasites by disrupting their metabolism and energy production.
Ivermectin 1% cream · Insel Gruppe AG, University Hospital Bern · Dermatology
Ivermectin binds to glutamate-gated chloride channels in parasites and arthropods, causing paralysis and death of the organisms.

Phase 3 pipeline (4)

Ivermectin Cream, 1% · Actavis Inc. · Dermatology
Ivermectin binds to glutamate-gated chloride channels in parasites and arthropods, causing paralysis and death of the organisms.
Ivermectin (reference) · Padagis LLC · Infectious Disease
Ivermectin binds to glutamate-gated chloride channels in parasitic organisms, causing paralysis and death of the parasite.
Generic Ivermectin Lotion 0.5% · Actavis Inc. · Dermatology / Parasitic Infections
Ivermectin binds to glutamate-gated chloride channels in parasitic organisms, causing paralysis and death of the parasite.
Sodium Stibogluconate (SSG) · U.S. Army Medical Research and Development Command · Infectious Disease
Sodium stibogluconate is a pentavalent antimony compound that kills Leishmania parasites by generating reactive oxygen species and inhibiting their glycolytic enzymes.