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Ivermectin 1% cream
Ivermectin 1% cream is a Antiparasitic agent Small molecule drug developed by Insel Gruppe AG, University Hospital Bern. It is currently FDA-approved for Rosacea (topical treatment of inflammatory lesions), Scabies (topical treatment). Also known as: Soolantra.
Ivermectin binds to glutamate-gated chloride channels in parasites and arthropods, causing paralysis and death of the organisms.
Ivermectin 1% cream is used to treat conditions such as head lice, scabies, and rosacea. It works by modulating the glutamate-gated chloride channel, a specific molecular target.
At a glance
| Generic name | Ivermectin 1% cream |
|---|---|
| Also known as | Soolantra |
| Sponsor | Insel Gruppe AG, University Hospital Bern |
| Drug class | Antiparasitic agent |
| Target | Glutamate-gated chloride channels |
| Modality | Small molecule |
| Therapeutic area | Dermatology |
| Phase | FDA-approved |
Mechanism of action
Ivermectin is a macrocyclic lactone that selectively activates glutamate-gated chloride ion channels in invertebrate nervous and muscular systems, leading to hyperpolarization, paralysis, and death of susceptible parasites and arthropods. In topical cream formulation, it penetrates the skin to reach mites and other ectoparasites in the dermis and epidermis. The mechanism is highly selective for invertebrate channels with minimal effects on mammalian physiology.
Approved indications
- Rosacea (topical treatment of inflammatory lesions)
- Scabies (topical treatment)
Common side effects
- Skin irritation or burning at application site
- Erythema
- Pruritus
Key clinical trials
- Ivermectin Safety in Small Children (PHASE2)
- Comparison of Permethrin and Ivermectin in Children Greater Than 6 Yrs Age for Treatment of Scabies (PHASE2)
- Potassium-titanyl Phosphate (KTP) Laser vs KTP Laser and Ivermectin Cream for Facial Rosacea (PHASE2)
- Bioequivalence Study of Ivermectin 1% Cream and Soolantra (Ivermectin) 10 mg/g Cream (PHASE1)
- Ivermectin/ Permethrin for Scabies (PHASE4)
- Comparative Study Between Topical Permethrin 5% and Oral Ivermectin for the Treatment of Scabies (PHASE1)
- Treatment of Ocular Demodex Infestation With Topical Ivermectin Cream 1% (PHASE1)
- Oracea Soolantra Association in Participants With Severe Rosacea (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ivermectin 1% cream CI brief — competitive landscape report
- Ivermectin 1% cream updates RSS · CI watch RSS
- Insel Gruppe AG, University Hospital Bern portfolio CI
Frequently asked questions about Ivermectin 1% cream
What is Ivermectin 1% cream?
How does Ivermectin 1% cream work?
What is Ivermectin 1% cream used for?
Who makes Ivermectin 1% cream?
Is Ivermectin 1% cream also known as anything else?
What drug class is Ivermectin 1% cream in?
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What does Ivermectin 1% cream target?
Related
- Drug class: All Antiparasitic agent drugs
- Target: All drugs targeting Glutamate-gated chloride channels
- Manufacturer: Insel Gruppe AG, University Hospital Bern — full pipeline
- Therapeutic area: All drugs in Dermatology
- Indication: Drugs for Rosacea (topical treatment of inflammatory lesions)
- Indication: Drugs for Scabies (topical treatment)
- Also known as: Soolantra
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing