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Generic Ivermectin Lotion 0.5%
Ivermectin binds to glutamate-gated chloride channels in parasitic organisms, causing paralysis and death of the parasite.
Ivermectin binds to glutamate-gated chloride channels in parasitic organisms, causing paralysis and death of the parasite. Used for Head lice infestation (Pediculosis capitis), Scabies (Sarcoptes scabiei).
At a glance
| Generic name | Generic Ivermectin Lotion 0.5% |
|---|---|
| Sponsor | Actavis Inc. |
| Drug class | Antiparasitic agent |
| Target | Glutamate-gated chloride channels |
| Modality | Small molecule |
| Therapeutic area | Dermatology / Parasitic Infections |
| Phase | Phase 3 |
Mechanism of action
Ivermectin is an antiparasitic agent that selectively binds to invertebrate-specific glutamate-gated chloride ion channels, increasing chloride conductance and hyperpolarizing the cell membrane. This leads to paralysis and death of susceptible parasites. The topical lotion formulation delivers the drug directly to affected skin areas for treatment of parasitic infestations.
Approved indications
- Head lice infestation (Pediculosis capitis)
- Scabies (Sarcoptes scabiei)
Common side effects
- Pruritus
- Erythema
- Skin irritation
- Burning sensation
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |