{"id":"generic-ivermectin-lotion-0-5","safety":{"commonSideEffects":[{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Skin irritation"},{"rate":null,"effect":"Burning sensation"}]},"_chembl":{"chemblId":"CHEMBL6067487","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Ivermectin is an antiparasitic agent that selectively binds to invertebrate-specific glutamate-gated chloride ion channels, increasing chloride conductance and hyperpolarizing the cell membrane. This leads to paralysis and death of susceptible parasites. The topical lotion formulation delivers the drug directly to affected skin areas for treatment of parasitic infestations.","oneSentence":"Ivermectin binds to glutamate-gated chloride channels in parasitic organisms, causing paralysis and death of the parasite.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:13:54.297Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Head lice infestation (Pediculosis capitis)"},{"name":"Scabies (Sarcoptes scabiei)"}]},"trialDetails":[{"nctId":"NCT03301649","phase":"PHASE3","title":"Clinical Endpoint Study of Ivermectin 0.5% Lotion","status":"COMPLETED","sponsor":"Actavis Inc.","startDate":"2017-10-07","conditions":"Head Lice","enrollment":905}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Generic Ivermectin Lotion 0.5%","genericName":"Generic Ivermectin Lotion 0.5%","companyName":"Actavis Inc.","companyId":"actavis-inc","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ivermectin binds to glutamate-gated chloride channels in parasitic organisms, causing paralysis and death of the parasite. Used for Head lice infestation (Pediculosis capitis), Scabies (Sarcoptes scabiei).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}