What are Antioxidant combination / Nutraceutical drugs?

Antioxidant combination / Nutraceutical drugs are pharmacologic agents that share a common mechanism (typically targeting PPAR-γ (rosiglitazone); mitochondrial oxidative stress (alpha-lipoic acid)). 4 are currently marketed, with 5 more in clinical development.

What are the marketed Antioxidant combination / Nutraceutical drugs?

Marketed Antioxidant combination / Nutraceutical drugs include Rutin + Vitamin C, Rosiglitazone/alpha-lipoic acid, Vitamins E + C, vitamin E +Selenium.

Antioxidant combination / Nutraceutical

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

4 marketed 5 in Phase 3

This page covers all Antioxidant combination / Nutraceutical drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting PPAR-γ (rosiglitazone); mitochondrial oxidative stress (alpha-lipoic acid), L-type calcium channel (diltiazem); glutathione synthesis pathway (acetylcysteine).

Targets

PPAR-γ (rosiglitazone); mitochondrial oxidative stress (alpha-lipoic acid) · L-type calcium channel (diltiazem); glutathione synthesis pathway (acetylcysteine)

Marketed (4)

Rutin + Vitamin C · Ain Shams University · Cardiovascular / Vascular health
Rutin and Vitamin C work synergistically as antioxidants to reduce oxidative stress and strengthen vascular integrity through free radical scavenging and collagen stabilization.
Rosiglitazone/alpha-lipoic acid · Seoul St. Mary's Hospital · Diabetes
Rosiglitazone improves insulin sensitivity by activating peroxisome proliferator-activated receptor gamma (PPAR-γ), while alpha-lipoic acid acts as an antioxidant to reduce oxidative stress and improve glucose metabolism.
Vitamins E + C · University Hospital, Aker · Nutritional support / General health
Vitamins E and C work as antioxidants to neutralize free radicals and reduce oxidative stress in the body.
vitamin E +Selenium · Tehran University of Medical Sciences · Nutritional supplementation / General wellness
Vitamin E and selenium work synergistically as antioxidants to reduce oxidative stress and support cellular protection.

Phase 3 pipeline (5)

Cytoflavin® enteric-coated tablet · POLYSAN Scientific & Technological Pharmaceutical Company · Neurology / Metabolic disorders
Cytoflavin is a combination drug that enhances cellular energy metabolism and reduces oxidative stress through its active components.
Cytoflavin® solution · POLYSAN Scientific & Technological Pharmaceutical Company · Neurology / Critical Care
Cytoflavin is a combination drug that enhances cellular energy metabolism and reduces oxidative stress through its active components.
diltiazem and acetylcystein · University Hospital, Strasbourg, France · Cardiovascular
This combination uses diltiazem to reduce calcium influx and improve cardiac function while acetylcysteine provides antioxidant and mucolytic support to protect against drug-induced injury.
Combined antioxidant therapy · University of Guadalajara
Combined antioxidant therapy works by neutralizing reactive oxygen species and reducing oxidative stress through multiple complementary antioxidant pathways.
Hydroxytyrosol plus Vitamin E · Bambino Gesù Hospital and Research Institute · Neurology
Hydroxytyrosol and Vitamin E work synergistically as antioxidants to reduce oxidative stress and inflammation.

Patent intelligence

antioxidant combination patent landscape — aggregated cliff calendar, attackable patents, originator estates