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diltiazem and acetylcystein

University Hospital, Strasbourg, France · Phase 3 active Small molecule

This combination uses diltiazem to reduce calcium influx and improve cardiac function while acetylcysteine provides antioxidant and mucolytic support to protect against drug-induced injury.

This combination uses diltiazem to reduce calcium influx and improve cardiac function while acetylcysteine provides antioxidant and mucolytic support to protect against drug-induced injury. Used for Investigational combination therapy in phase 3 (specific indication not publicly detailed).

At a glance

Generic namediltiazem and acetylcystein
Also known asCombined diltiazem and acetylcystein drug group
SponsorUniversity Hospital, Strasbourg, France
Drug classCalcium channel blocker + antioxidant combination
TargetL-type calcium channel (diltiazem); glutathione synthesis pathway (acetylcysteine)
ModalitySmall molecule
Therapeutic areaCardiovascular
PhasePhase 3

Mechanism of action

Diltiazem is a non-dihydropyridine calcium channel blocker that decreases intracellular calcium, reducing cardiac contractility and heart rate, commonly used for arrhythmias and angina. Acetylcysteine is a thiol-containing antioxidant that replenishes glutathione stores and scavenges reactive oxygen species, potentially protecting tissues from oxidative stress and drug toxicity. The combination may be investigated for cardioprotection or to mitigate diltiazem-related adverse effects in specific cardiac conditions.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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