Last reviewed 2026-04-22 · How we verify

Cytoflavin® solution

Cytoflavin is a combination drug that enhances cellular energy metabolism and reduces oxidative stress through its active components.

Cytoflavin is a combination drug that enhances cellular energy metabolism and reduces oxidative stress through its active components. Used for Acute ischemic stroke, Traumatic brain injury, Hypoxic-ischemic encephalopathy.

At a glance

Mechanism of action

Cytoflavin contains succinic acid and flavin mononucleotide (riboflavin derivative), which work synergistically to improve mitochondrial function and ATP production. It acts as an antioxidant and metabolic activator, helping restore cellular energy metabolism in conditions characterized by hypoxia or metabolic dysfunction.

Approved indications

• Acute ischemic stroke
• Traumatic brain injury
• Hypoxic-ischemic encephalopathy
• Acute cerebrovascular disorders

Common side effects

• Headache
• Dizziness
• Nausea
• Injection site reactions

Key clinical trials

• Cytoflavin in the Complex Rehabilitation of Stroke Patients (PHASE3)
• Observational Study of Efficiency of Cytoflavin, in Patients With Ischemic Stroke Not Receiving Reperfusion Therapy
• International Trial of Efficacy of Cytoflavin in Head Trauma (PHASE3)
• Evaluation of the Efficacy of Permanent Course Combined Therapy With CYTOFLAVIN® Intravenous Solution and CYTOFLAVIN Tablets, at 2-3 Stages of Rehabilitation of Patients With Post Intensive Care Syndrome
• Cytoflavin in the Rehabilitation of Post-intensive Care Syndrome in Stroke Survivors
• Cytoflavin in Combination With Reperfusion in Stroke Patients
• Efficacy and Safety of Cytoflavin® Used in Elderly Patients for the Prevention of Cognitive Decline After Major Surgery (PHASE3)
• Cytoflavin in the Treatment of Patients With Diabetic Polyneuropathy (PHASE3)

Primary sources

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