Antimalarial combination therapy

This page covers all Antimalarial combination therapy drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Plasmodium falciparum heme polymerase; artemisinin-derived endoperoxide bridge, Plasmodium falciparum (malaria parasite), Plasmodium falciparum dihydrofolate reductase (sulfadoxine-pyrimethamine); hemozoin formation (piperaquine).

Targets

Plasmodium falciparum heme polymerase; artemisinin-derived endoperoxide bridge · Plasmodium falciparum (malaria parasite) · Plasmodium falciparum dihydrofolate reductase (sulfadoxine-pyrimethamine); hemozoin formation (piperaquine) · Plasmodium falciparum heme metabolism and protein synthesis · Plasmodium falciparum (multiple parasite targets including heme detoxification pathway and DNA synthesis) · Malaria parasite heme metabolism and hemozoin formation · Multiple: artemisinin (heme-dependent mechanism), mefloquine (heme polymerization inhibition), piperaquine (heme polymerization inhibition) · Plasmodium falciparum (multiple targets: artemisinin-induced oxidative stress, dihydrofolate reductase) · Multiple: heme polymerase, mitochondrial electron transport, gametocyte development · Plasmodium falciparum dihydrofolate reductase, dihydropteroate synthase, and quinoline-sensitive targets

Marketed (7)

• Amodiaquine-artesunate (ASAQ) · Centers for Disease Control and Prevention · Infectious Disease
  ASAQ is a fixed-dose combination of amodiaquine (a 4-aminoquinoline) and artesunate (an artemisinin derivative) that kills malaria parasites through complementary mechanisms involving heme detoxification disruption and rapid parasite clearance.
• IPTp-DP · Kenya Medical Research Institute · Infectious Disease / Parasitology
  IPTp-DP is a dihydroartemisinin-piperaquine combination that prevents malaria infection in pregnant women by killing malaria parasites in the blood.
• SP-IPTp · London School of Hygiene and Tropical Medicine · Infectious Disease / Parasitology
  SP-IPTp is a seasonal malaria chemoprevention regimen combining sulfadoxine-pyrimethamine with piperaquine to prevent malaria in pregnant women and children.
• WHO-recommended periodic presumptive treatment · University of Washington · Infectious Disease / Parasitology
  WHO-recommended periodic presumptive treatment (PPT) involves administering antimalarial drugs at regular intervals to pregnant women or other at-risk populations to prevent malaria infection regardless of parasitemia status.
• Coadministered Artesunate plus Amodiaquine · Professor Anders Björkman · Infectious Disease
  Artesunate and amodiaquine work synergistically to kill malaria parasites through distinct mechanisms: artesunate generates reactive oxygen species that damage parasite proteins and DNA, while amodiaquine inhibits parasite heme detoxification.
• Artesunate plus Amodiaquine · Bernhard Nocht Institute for Tropical Medicine · Infectious Disease
  Artesunate and amodiaquine work synergistically to kill malaria parasites by generating reactive oxygen species and disrupting parasite metabolism.
• lumefantrine plus artemether · Centers for Disease Control and Prevention · Infectious Disease
  Lumefantrine and artemether work together as antimalarial agents that kill malaria parasites through distinct mechanisms involving heme detoxification and rapid parasite clearance.

Phase 3 pipeline (9)

• Artesunate-mefloquine+piperaquine · University of Oxford · Infectious Disease
  This combination of three antimalarial agents works by disrupting parasite metabolism and preventing drug resistance through multiple complementary mechanisms of action.
• Artesunate+Sulfamethoxypyrazine/pyrimethamine · Kenya Medical Research Institute · Infectious Disease
  This combination drug uses artesunate to disrupt malaria parasite metabolism while sulfamethoxypyrazine and pyrimethamine inhibit folate synthesis pathways essential for parasite survival.
• SP, chloroquine, amodiaquine, primaquine, artesunate · London School of Hygiene and Tropical Medicine · Infectious Disease / Parasitology
  This is a fixed-dose combination of antimalarial drugs that work through multiple mechanisms to kill malaria parasites and reduce transmission.
• SMC with SP+AQ · London School of Hygiene and Tropical Medicine · Infectious Disease / Parasitology
  SMC with SP+AQ is a seasonal malaria chemoprevention regimen combining sulfadoxine-pyrimethamine and amodiaquine to prevent malaria infection in children during high-transmission seasons.
• Mefloquine plus artesunate · Medicines for Malaria Venture · Infectious Disease
  This combination uses mefloquine (a quinoline antimalarial) and artesunate (an artemisinin derivative) to kill malaria parasites through complementary mechanisms that reduce drug resistance.
• azithromycin, sulphadoxine pyrimethamine, LLIN · University of Melbourne · Infectious Disease / Parasitology
  This combination uses azithromycin (antibiotic), sulphadoxine-pyrimethamine (antimalarial), and long-lasting insecticidal nets (LLIN) to prevent and treat malaria through multiple mechanisms including parasite inhibition and mosquito vector control.
• primaquine (PQ) plus SP+AS · London School of Hygiene and Tropical Medicine · Infectious Disease
  Primaquine plus sulfadoxine-pyrimethamine and artesunate works by killing malaria parasites at multiple lifecycle stages, including the dormant liver forms that cause relapse.
• Artesunate-amodiaquine + primaquine · University of Oxford · Infectious Disease
  This combination therapy kills malaria parasites through multiple mechanisms: artesunate and amodiaquine target the parasite's hemoglobin digestion and DNA replication, while primaquine eliminates dormant liver stages and gametocytes to prevent transmission and relapse.
• DHA-PQP and PQ starting on Day 42 · Fundação de Medicina Tropical Dr. Heitor Vieira Dourado · Infectious Disease
  DHA-PQP and PQ are antimalarial combination drugs that work by disrupting parasite metabolism and preventing malaria transmission.