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Artesunate+Sulfamethoxypyrazine/pyrimethamine
Artesunate+Sulfamethoxypyrazine/pyrimethamine is a Antimalarial combination therapy Small molecule drug developed by Kenya Medical Research Institute. It is currently in Phase 3 development for Malaria (Plasmodium falciparum infection). Also known as: Co-arinate FDC.
This combination drug uses artesunate to disrupt malaria parasite metabolism while sulfamethoxypyrazine and pyrimethamine inhibit folate synthesis pathways essential for parasite survival.
This combination drug uses artesunate to disrupt malaria parasite metabolism while sulfamethoxypyrazine and pyrimethamine inhibit folate synthesis pathways essential for parasite survival. Used for Malaria (Plasmodium falciparum infection).
At a glance
| Generic name | Artesunate+Sulfamethoxypyrazine/pyrimethamine |
|---|---|
| Also known as | Co-arinate FDC |
| Sponsor | Kenya Medical Research Institute |
| Drug class | Antimalarial combination therapy |
| Target | Plasmodium falciparum (multiple targets: artemisinin-induced oxidative stress, dihydrofolate reductase) |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease |
| Phase | Phase 3 |
Mechanism of action
Artesunate is an artemisinin derivative that generates reactive oxygen species and damages parasite proteins and membranes. Sulfamethoxypyrazine and pyrimethamine are antifolate agents that inhibit dihydrofolate reductase and other enzymes in the folate synthesis pathway, preventing nucleotide production necessary for parasite DNA replication. The combination provides synergistic antimalarial activity through complementary mechanisms.
Approved indications
- Malaria (Plasmodium falciparum infection)
Common side effects
- Gastrointestinal disturbances (nausea, vomiting, diarrhea)
- Headache
- Fever
- Hematologic effects (anemia, thrombocytopenia)
- Hepatotoxicity
Key clinical trials
- A Randomised Trial of Artesunate-sulfamethoxypyrazine/Pyrimethamine Versus Praziquantel for the Treatment of S. Mansoni (PHASE3)
- Multi-Centre Trial Comparing Three Artemisinin-Based Combination Treatments on P. Falciparum Malaria (PHASE3)
- Comparing Praziquantel Versus Artesunate + Sulfamethoxypyrazine/Pyrimethamine for Treating Schistosomiasis (PHASE2, PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Artesunate+Sulfamethoxypyrazine/pyrimethamine CI brief — competitive landscape report
- Artesunate+Sulfamethoxypyrazine/pyrimethamine updates RSS · CI watch RSS
- Kenya Medical Research Institute portfolio CI
Frequently asked questions about Artesunate+Sulfamethoxypyrazine/pyrimethamine
What is Artesunate+Sulfamethoxypyrazine/pyrimethamine?
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Is Artesunate+Sulfamethoxypyrazine/pyrimethamine also known as anything else?
What drug class is Artesunate+Sulfamethoxypyrazine/pyrimethamine in?
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Related
- Drug class: All Antimalarial combination therapy drugs
- Target: All drugs targeting Plasmodium falciparum (multiple targets: artemisinin-induced oxidative stress, dihydrofolate reductase)
- Manufacturer: Kenya Medical Research Institute — full pipeline
- Therapeutic area: All drugs in Infectious Disease
- Indication: Drugs for Malaria (Plasmodium falciparum infection)
- Also known as: Co-arinate FDC
- Compare: Artesunate+Sulfamethoxypyrazine/pyrimethamine vs similar drugs
- Pricing: Artesunate+Sulfamethoxypyrazine/pyrimethamine cost, discount & access