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SP, chloroquine, amodiaquine, primaquine, artesunate

London School of Hygiene and Tropical Medicine · Phase 3 active Small molecule

SP, chloroquine, amodiaquine, primaquine, artesunate is a Antimalarial combination therapy Small molecule drug developed by London School of Hygiene and Tropical Medicine. It is currently in Phase 3 development for Malaria treatment and transmission reduction (phase 3 development).

This is a fixed-dose combination of antimalarial drugs that work through multiple mechanisms to kill malaria parasites and reduce transmission.

This is a fixed-dose combination of antimalarial drugs that work through multiple mechanisms to kill malaria parasites and reduce transmission. Used for Malaria treatment and transmission reduction (phase 3 development).

At a glance

Generic nameSP, chloroquine, amodiaquine, primaquine, artesunate
SponsorLondon School of Hygiene and Tropical Medicine
Drug classAntimalarial combination therapy
TargetMultiple: heme polymerase, mitochondrial electron transport, gametocyte development
ModalitySmall molecule
Therapeutic areaInfectious Disease / Parasitology
PhasePhase 3

Mechanism of action

The combination includes chloroquine and amodiaquine (quinoline antimalarials that inhibit heme polymerization in parasites), primaquine (an 8-aminoquinoline that targets hypnozoites and gametocytes), and artesunate (an artemisinin derivative that generates reactive oxygen species). Together, these agents target different parasite life stages and reduce both clinical malaria and transmission potential.

Approved indications

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

Competitive intelligence

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Frequently asked questions about SP, chloroquine, amodiaquine, primaquine, artesunate

What is SP, chloroquine, amodiaquine, primaquine, artesunate?

SP, chloroquine, amodiaquine, primaquine, artesunate is a Antimalarial combination therapy drug developed by London School of Hygiene and Tropical Medicine, indicated for Malaria treatment and transmission reduction (phase 3 development).

How does SP, chloroquine, amodiaquine, primaquine, artesunate work?

This is a fixed-dose combination of antimalarial drugs that work through multiple mechanisms to kill malaria parasites and reduce transmission.

What is SP, chloroquine, amodiaquine, primaquine, artesunate used for?

SP, chloroquine, amodiaquine, primaquine, artesunate is indicated for Malaria treatment and transmission reduction (phase 3 development).

Who makes SP, chloroquine, amodiaquine, primaquine, artesunate?

SP, chloroquine, amodiaquine, primaquine, artesunate is developed by London School of Hygiene and Tropical Medicine (see full London School of Hygiene and Tropical Medicine pipeline at /company/london-school-of-hygiene-and-tropical-medicine).

What drug class is SP, chloroquine, amodiaquine, primaquine, artesunate in?

SP, chloroquine, amodiaquine, primaquine, artesunate belongs to the Antimalarial combination therapy class. See all Antimalarial combination therapy drugs at /class/antimalarial-combination-therapy.

What development phase is SP, chloroquine, amodiaquine, primaquine, artesunate in?

SP, chloroquine, amodiaquine, primaquine, artesunate is in Phase 3.

What are the side effects of SP, chloroquine, amodiaquine, primaquine, artesunate?

Common side effects of SP, chloroquine, amodiaquine, primaquine, artesunate include Gastrointestinal disturbance (nausea, vomiting, diarrhea), Headache, Hemolysis (primaquine-related, in G6PD deficiency), Pruritus, Dizziness.

What does SP, chloroquine, amodiaquine, primaquine, artesunate target?

SP, chloroquine, amodiaquine, primaquine, artesunate targets Multiple: heme polymerase, mitochondrial electron transport, gametocyte development and is a Antimalarial combination therapy.

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