{"id":"sp-chloroquine-amodiaquine-primaquine-artesunate","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbance (nausea, vomiting, diarrhea)"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Hemolysis (primaquine-related, in G6PD deficiency)"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Dizziness"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"The combination includes chloroquine and amodiaquine (quinoline antimalarials that inhibit heme polymerization in parasites), primaquine (an 8-aminoquinoline that targets hypnozoites and gametocytes), and artesunate (an artemisinin derivative that generates reactive oxygen species). Together, these agents target different parasite life stages and reduce both clinical malaria and transmission potential.","oneSentence":"This is a fixed-dose combination of antimalarial drugs that work through multiple mechanisms to kill malaria parasites and reduce transmission.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:53:23.187Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Malaria treatment and transmission reduction (phase 3 development)"}]},"trialDetails":[{"nctId":"NCT00158548","phase":"PHASE3","title":"ACT With Chloroquine, Amodiaquine & Sulphadoxine-pyrimethamine in Pakistan","status":"COMPLETED","sponsor":"London School of Hygiene and Tropical Medicine","startDate":"2001-06","conditions":"Malaria, Falciparum Malaria, Vivax Malaria","enrollment":650}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"SP, chloroquine, amodiaquine, primaquine, artesunate","genericName":"SP, chloroquine, amodiaquine, primaquine, artesunate","companyName":"London School of Hygiene and Tropical Medicine","companyId":"london-school-of-hygiene-and-tropical-medicine","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This is a fixed-dose combination of antimalarial drugs that work through multiple mechanisms to kill malaria parasites and reduce transmission. Used for Malaria treatment and transmission reduction (phase 3 development).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}