SP, chloroquine, amodiaquine, primaquine, artesunate — Competitive Intelligence Brief

SP, chloroquine, amodiaquine, primaquine, artesunate (SP, chloroquine, amodiaquine, primaquine, artesunate) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Antimalarial combination therapy. Area: Infectious Disease / Parasitology.

phase 3 Antimalarial combination therapy Multiple: heme polymerase, mitochondrial electron transport, gametocyte development Infectious Disease / Parasitology Small molecule

Target snapshot

SP, chloroquine, amodiaquine, primaquine, artesunate (SP, chloroquine, amodiaquine, primaquine, artesunate) — London School of Hygiene and Tropical Medicine. This is a fixed-dose combination of antimalarial drugs that work through multiple mechanisms to kill malaria parasites and reduce transmission.

Comparator set (6 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
SP, chloroquine, amodiaquine, primaquine, artesunate TARGET	SP, chloroquine, amodiaquine, primaquine, artesunate	London School of Hygiene and Tropical Medicine	phase 3	Antimalarial combination therapy	Multiple: heme polymerase, mitochondrial electron transport, gametocyte development
lumefantrine plus artemether	lumefantrine plus artemether	Centers for Disease Control and Prevention	marketed	Antimalarial combination therapy	Malaria parasite heme metabolism and hemozoin formation
IPTp-DP	IPTp-DP	Kenya Medical Research Institute	marketed	Antimalarial combination therapy	Plasmodium falciparum (malaria parasite)
Artesunate plus Amodiaquine	Artesunate plus Amodiaquine	Bernhard Nocht Institute for Tropical Medicine	marketed	Antimalarial combination therapy	Plasmodium falciparum (multiple parasite targets including heme detoxification pathway and DNA synthesis)
SP-IPTp	SP-IPTp	London School of Hygiene and Tropical Medicine	marketed	Antimalarial combination therapy	Plasmodium falciparum dihydrofolate reductase (sulfadoxine-pyrimethamine); hemozoin formation (piperaquine)
WHO-recommended periodic presumptive treatment	WHO-recommended periodic presumptive treatment	University of Washington	marketed	Antimalarial combination therapy
Coadministered Artesunate plus Amodiaquine	Coadministered Artesunate plus Amodiaquine	Professor Anders Björkman	marketed	Antimalarial combination therapy	Plasmodium falciparum heme metabolism and protein synthesis

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Antimalarial combination therapy class)

1. London School of Hygiene and Tropical Medicine · 4 drugs in this class
2. Kenya Medical Research Institute · 2 drugs in this class
3. University of Oxford · 2 drugs in this class
4. Centers for Disease Control and Prevention · 2 drugs in this class
5. University of Melbourne · 1 drug in this class
6. Bernhard Nocht Institute for Tropical Medicine · 1 drug in this class
7. University of Washington · 1 drug in this class
8. Fundação de Medicina Tropical Dr. Heitor Vieira Dourado · 1 drug in this class
9. Medicines for Malaria Venture · 1 drug in this class
10. Professor Anders Björkman · 1 drug in this class