Who are Tramadol PR oral's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Tramadol HCl, Tramadol /acetaminophen, Tramadol IV (Tradonal® IV), Tramal®, Tramadol OAD, Tramadol 50.

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Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-16 · How we verify

Tramadol PR oral — Competitive Intelligence Brief

Tramadol PR oral (Tramadol PR oral) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Opioid analgesic with monoamine reuptake inhibition. Area: Pain Management.

phase 3 Opioid analgesic with monoamine reuptake inhibition Mu opioid receptor; norepinephrine transporter; serotonin transporter Pain Management Biologic Live · refreshed every 30 min

Target snapshot

Tramadol PR oral (Tramadol PR oral) — Pfizer. Tramadol is a synthetic opioid analgesic that binds to mu opioid receptors and also inhibits the reuptake of norepinephrine and serotonin to provide pain relief.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
Tramadol PR oral TARGET	Tramadol PR oral	Pfizer	phase 3	Opioid analgesic with monoamine reuptake inhibition	Mu opioid receptor; norepinephrine transporter; serotonin transporter
Tramadol HCl	Tramadol HCl	Labopharm Inc.	marketed	Synthetic opioid analgesic with monoamine reuptake inhibition	Mu opioid receptor; norepinephrine transporter; serotonin transporter
Tramadol /acetaminophen	Tramadol /acetaminophen	Johnson & Johnson Taiwan Ltd	marketed	Opioid analgesic combination	Mu opioid receptor; norepinephrine transporter; serotonin transporter; cyclooxygenase
Tramadol IV (Tradonal® IV)	Tramadol IV (Tradonal® IV)	University Hospital, Ghent	marketed	Opioid analgesic with monoamine reuptake inhibition	Mu opioid receptor; norepinephrine transporter; serotonin transporter
Tramal®	Tramal®	Apsen Farmaceutica S.A.	marketed	Synthetic opioid analgesic	Mu opioid receptor; norepinephrine transporter; serotonin transporter
Tramadol OAD	Tramadol OAD	Labopharm Inc.	phase 3	Opioid analgesic with norepinephrine-serotonin reuptake inhibition	Mu opioid receptor; norepinephrine transporter; serotonin transporter
Tramadol 50	Tramadol 50	Grünenthal GmbH	phase 3	Synthetic opioid analgesic	Mu opioid receptor; norepinephrine transporter; serotonin transporter

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Opioid analgesic with monoamine reuptake inhibition class)

Al-Azhar University · 1 drug in this class
Pfizer · 1 drug in this class
University Hospital, Ghent · 1 drug in this class
University of Southern Denmark · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Tramadol PR oral — Competitive Intelligence Brief. https://druglandscape.com/ci/tramadol-pr-oral. Accessed 2026-05-16.

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