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Tramadol 50
Tramadol is a synthetic opioid analgesic that binds to mu opioid receptors and also inhibits the reuptake of norepinephrine and serotonin to provide pain relief.
Tramadol is a synthetic opioid analgesic that binds to mu opioid receptors and also inhibits the reuptake of norepinephrine and serotonin to provide pain relief. Used for Moderate acute and chronic pain.
At a glance
| Generic name | Tramadol 50 |
|---|---|
| Also known as | Tramadol immediate-release capsule, Tradol (Registered Trademark) |
| Sponsor | Grünenthal GmbH |
| Drug class | Synthetic opioid analgesic |
| Target | Mu opioid receptor; norepinephrine transporter; serotonin transporter |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | Phase 3 |
Mechanism of action
Tramadol works through dual mechanisms: it acts as a weak mu opioid receptor agonist and simultaneously inhibits the reuptake of norepinephrine and serotonin in the central nervous system. This combination of opioid and monoamine reuptake inhibition produces analgesic effects for moderate pain. The norepinephrine and serotonin reuptake inhibition component contributes significantly to its pain-relieving properties and distinguishes it from traditional opioids.
Approved indications
- Moderate acute and chronic pain
Common side effects
- Dizziness
- Nausea
- Constipation
- Headache
- Somnolence
- Vomiting
- Pruritus
- Sweating
Key clinical trials
- Comparison of Postoperative Analgesic Efficacy of Interscalene and Suprascapular Blocks Used in Arthroscopic Shoulder Surgery
- Efficacy And Safety Of Tramadol And Oxycodone Versus Oxycodone Monotherapy For Pain Control After Primary Total Knee And Total Hip Arthroplasty (PHASE4)
- Safety and Efficacy of Dexmedetomidate vs. Midazolam for Procedural Sedation During Medical Thoracoscopy (PHASE3)
- Postoperative Analgesia and Ventilation After Cardiac Surgery
- ERAS (Enhanced Recovery After Surgery) and Multimodal Analgesia in Laparoscopic Cholecystectomy
- Opioid-Free vs Opioid-Based Anesthesia in Bariatric Surgery (NA)
- Comparison of the Postoperative Analgesic Effects of SPSIPB and TPB in Mastectomy Operations (NA)
- Efficacy of Transversus Abdominis Plane Block in Alleviating Acute Appendicitis (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Tramadol 50 CI brief — competitive landscape report
- Tramadol 50 updates RSS · CI watch RSS
- Grünenthal GmbH portfolio CI