{"id":"tramadol-50","safety":{"commonSideEffects":[{"rate":"25-30","effect":"Dizziness"},{"rate":"24-30","effect":"Nausea"},{"rate":"24-46","effect":"Constipation"},{"rate":"18-20","effect":"Headache"},{"rate":"16-25","effect":"Somnolence"},{"rate":"5-17","effect":"Vomiting"},{"rate":"8-10","effect":"Pruritus"},{"rate":"6-9","effect":"Sweating"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Tramadol works through dual mechanisms: it acts as a weak mu opioid receptor agonist and simultaneously inhibits the reuptake of norepinephrine and serotonin in the central nervous system. This combination of opioid and monoamine reuptake inhibition produces analgesic effects for moderate pain. The norepinephrine and serotonin reuptake inhibition component contributes significantly to its pain-relieving properties and distinguishes it from traditional opioids.","oneSentence":"Tramadol is a synthetic opioid analgesic that binds to mu opioid receptors and also inhibits the reuptake of norepinephrine and serotonin to provide pain relief.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:39:47.173Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Moderate acute and chronic pain"}]},"trialDetails":[{"nctId":"NCT07483814","phase":"","title":"Comparison of Postoperative Analgesic Efficacy of Interscalene and Suprascapular Blocks Used in Arthroscopic Shoulder Surgery","status":"ACTIVE_NOT_RECRUITING","sponsor":"Aydin Adnan Menderes University","startDate":"2024-01-01","conditions":"Postoperative Acute Pain, Chronic Pain","enrollment":84},{"nctId":"NCT07153003","phase":"PHASE4","title":"Efficacy And Safety Of Tramadol And Oxycodone Versus 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