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Tramadol IV (Tradonal® IV)
Tramadol is an opioid analgesic that binds to mu opioid receptors and also inhibits the reuptake of norepinephrine and serotonin to provide pain relief.
Tramadol is an opioid analgesic that binds to mu opioid receptors and also inhibits the reuptake of norepinephrine and serotonin to provide pain relief. Used for Moderate to severe acute pain (postoperative pain, trauma-related pain), Severe pain requiring parenteral opioid therapy.
At a glance
| Generic name | Tramadol IV (Tradonal® IV) |
|---|---|
| Sponsor | University Hospital, Ghent |
| Drug class | Opioid analgesic with monoamine reuptake inhibition |
| Target | Mu opioid receptor; norepinephrine transporter; serotonin transporter |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | FDA-approved |
Mechanism of action
Tramadol works through dual mechanisms: it acts as a weak mu opioid receptor agonist and simultaneously inhibits the reuptake of norepinephrine and serotonin in the central nervous system. This combination of opioid and monoamine reuptake inhibition produces analgesic effects for moderate pain. The IV formulation allows for rapid onset and is typically used for acute postoperative or severe pain management in hospital settings.
Approved indications
- Moderate to severe acute pain (postoperative pain, trauma-related pain)
- Severe pain requiring parenteral opioid therapy
Common side effects
- Nausea
- Dizziness
- Headache
- Vomiting
- Constipation
- Somnolence
- Seizures (at high doses)
- Respiratory depression
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |