{"id":"tramadol-iv-tradonal-iv","safety":{"commonSideEffects":[{"rate":"10-20","effect":"Nausea"},{"rate":"10-15","effect":"Dizziness"},{"rate":"5-10","effect":"Headache"},{"rate":"5-10","effect":"Vomiting"},{"rate":"5-10","effect":"Constipation"},{"rate":"5-10","effect":"Somnolence"},{"rate":"<1","effect":"Seizures (at high doses)"},{"rate":"1-5","effect":"Respiratory depression"}]},"_chembl":{"chemblId":"CHEMBL3121562","moleculeType":"Small molecule","molecularWeight":"784.98"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Tramadol works through dual mechanisms: it acts as a weak mu opioid receptor agonist and simultaneously inhibits the reuptake of norepinephrine and serotonin in the central nervous system. This combination of opioid and monoamine reuptake inhibition produces analgesic effects for moderate pain. The IV formulation allows for rapid onset and is typically used for acute postoperative or severe pain management in hospital settings.","oneSentence":"Tramadol is an opioid analgesic that binds to mu opioid receptors and also inhibits the reuptake of norepinephrine and serotonin to provide pain relief.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:13:29.905Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Moderate to severe acute pain (postoperative pain, trauma-related pain)"},{"name":"Severe pain requiring parenteral opioid therapy"}]},"trialDetails":[{"nctId":"NCT00735748","phase":"PHASE4","title":"Comparison of Tramadol Orally Versus an Optimized Dose of Intravenous Tramadol for Postoperative Pain Relief in Ambulatory Surgery","status":"COMPLETED","sponsor":"University Hospital, Ghent","startDate":"2008-03-01","conditions":"Pain","enrollment":195}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Tramadol IV (Tradonal® IV)","genericName":"Tramadol IV (Tradonal® IV)","companyName":"University Hospital, Ghent","companyId":"university-hospital-ghent","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tramadol is an opioid analgesic that binds to mu opioid receptors and also inhibits the reuptake of norepinephrine and serotonin to provide pain relief. Used for Moderate to severe acute pain (postoperative pain, trauma-related pain), Severe pain requiring parenteral opioid therapy.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}