Who are placebo and tramadol's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Tramadol HCl/acetaminophen Extended Release, Tramadol hydrochloride/ Acetaminophen, Tramadol hydrochloride/Acetaminophen Tab., Tramadol IV (Tradonal® IV), Tramadol HCl, Tramadol 5%.

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Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-16 · How we verify

placebo and tramadol — Competitive Intelligence Brief

placebo and tramadol (placebo and tramadol) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Opioid analgesic with monoamine reuptake inhibition. Area: Pain Management.

marketed Opioid analgesic with monoamine reuptake inhibition Mu-opioid receptor; norepinephrine transporter; serotonin transporter Pain Management Small molecule Live · refreshed every 30 min

Target snapshot

placebo and tramadol (placebo and tramadol) — University of Southern Denmark. Tramadol is a synthetic opioid analgesic that inhibits reuptake of norepinephrine and serotonin while also acting as a weak mu-opioid receptor agonist to provide pain relief.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target
placebo and tramadol TARGET	placebo and tramadol	University of Southern Denmark	marketed	Opioid analgesic with monoamine reuptake inhibition	Mu-opioid receptor; norepinephrine transporter; serotonin transporter
Tramadol HCl/acetaminophen Extended Release	Tramadol HCl/acetaminophen Extended Release	Janssen Korea, Ltd., Korea	marketed	Opioid analgesic combination with NSAID alternative	Mu-opioid receptor; norepinephrine transporter; serotonin transporter
Tramadol hydrochloride/ Acetaminophen	Tramadol hydrochloride/ Acetaminophen	Janssen Korea, Ltd., Korea	marketed	Opioid analgesic combination	Mu-opioid receptor; norepinephrine transporter; serotonin transporter
Tramadol hydrochloride/Acetaminophen Tab.	Tramadol hydrochloride/Acetaminophen Tab.	Daewon Pharmaceutical Co., Ltd.	phase 3	Opioid analgesic combination	Mu-opioid receptor; norepinephrine transporter; serotonin transporter
Tramadol IV (Tradonal® IV)	Tramadol IV (Tradonal® IV)	University Hospital, Ghent	marketed	Opioid analgesic with monoamine reuptake inhibition	Mu opioid receptor; norepinephrine transporter; serotonin transporter
Tramadol HCl	Tramadol HCl	Labopharm Inc.	marketed	Synthetic opioid analgesic with monoamine reuptake inhibition	Mu opioid receptor; norepinephrine transporter; serotonin transporter
Tramadol 5%	Tramadol 5%	Al-Azhar University	phase 3	Opioid analgesic with monoamine reuptake inhibition	Mu opioid receptor; norepinephrine and serotonin transporters

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Opioid analgesic with monoamine reuptake inhibition class)

Al-Azhar University · 1 drug in this class
Pfizer · 1 drug in this class
University Hospital, Ghent · 1 drug in this class
University of Southern Denmark · 1 drug in this class

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Cite this brief

Drug Landscape (2026). placebo and tramadol — Competitive Intelligence Brief. https://druglandscape.com/ci/placebo-and-tramadol. Accessed 2026-05-16.

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