Intraoperative Intravenous Lidocaine Infusion — Competitive Intelligence Brief

Intraoperative Intravenous Lidocaine Infusion (Intraoperative Intravenous Lidocaine Infusion) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Local anesthetic / Sodium channel blocker. Area: Perioperative pain management / Surgery.

phase 3 Local anesthetic / Sodium channel blocker Voltage-gated sodium channels Perioperative pain management / Surgery Small molecule

Target snapshot

Intraoperative Intravenous Lidocaine Infusion (Intraoperative Intravenous Lidocaine Infusion) — McMaster University. Lidocaine blocks sodium channels in nerve fibers, reducing pain signal transmission and providing local anesthetic and analgesic effects during surgery.

Comparator set (6 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Intraoperative Intravenous Lidocaine Infusion TARGET	Intraoperative Intravenous Lidocaine Infusion	McMaster University	phase 3	Local anesthetic / Sodium channel blocker	Voltage-gated sodium channels
Bupivacaine liposomal injectable suspension	Bupivacaine liposomal injectable suspension	The University of Texas Health Science Center, Houston	marketed	Local anesthetic (liposomal formulation)	Voltage-gated sodium channels
Bupivacaine + nalbuphine	Bupivacaine + nalbuphine	Alzahraa Ahmed Abbas	marketed	Local anesthetic + mixed opioid agonist-antagonist	Voltage-gated sodium channels (bupivacaine); kappa and mu opioid receptors (nalbuphine)
Ropivacaine + Midazolam	Ropivacaine + Midazolam	Aga Khan University	marketed	Local anesthetic + benzodiazepine combination	Voltage-gated sodium channels (ropivacaine); GABA-A receptors (midazolam)
Bupivacaine standard dose	Bupivacaine standard dose	Fundacion para la Investigacion Biomedica del Hospital Universitario Principe de Asturias	marketed	Local anesthetic (amide)	Voltage-gated sodium channels
Compound lidocaine	Compound lidocaine	Tianjin Medical University General Hospital	marketed	Local anesthetic	Voltage-gated sodium channels
Buffered Lidocaine	Buffered Lidocaine	University of California, San Diego	marketed	Local anesthetic	Voltage-gated sodium channels

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Local anesthetic / Sodium channel blocker class)

1. McMaster University · 1 drug in this class
2. Medical University of Warsaw · 1 drug in this class