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Bupivacaine standard dose
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of nerve impulses.
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of nerve impulses. Used for Local and regional anesthesia for surgical procedures, Infiltration anesthesia, Nerve blocks.
At a glance
| Generic name | Bupivacaine standard dose |
|---|---|
| Sponsor | Fundacion para la Investigacion Biomedica del Hospital Universitario Principe de Asturias |
| Drug class | Local anesthetic (amide) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine reversibly inhibits sodium influx into nerve fibers by binding to sodium channels from the intracellular side, thereby stabilizing the neuronal membrane and raising the threshold for electrical excitability. This action prevents depolarization and conduction of action potentials, resulting in local anesthesia. It is an amide-type local anesthetic with a longer duration of action compared to other local anesthetics.
Approved indications
- Local and regional anesthesia for surgical procedures
- Infiltration anesthesia
- Nerve blocks
- Epidural anesthesia
- Spinal anesthesia
Common side effects
- Hypotension
- Bradycardia
- Dizziness
- Nervousness
- Tremor
- Nausea
- Systemic toxicity (CNS and cardiac effects at high doses)
Key clinical trials
- Effect of Scalp Block on Intraoperative Hemodynamics and Postoperative Pain in Craniotomy Patients" (NA)
- ERAS (Enhanced Recovery After Surgery) and Multimodal Analgesia in Laparoscopic Cholecystectomy
- Epidural vs. Dural Puncture Epidural in Labor Analgesia (NA)
- Effect of Bilateral Rhomboid Intercostal Block on Postoperative Pain After Breast Implant Surgery (NA)
- Comparison of Post-Dural Puncture Headache After Spinal Anesthesia Using Median Versus Paramedian Approach (NA)
- AI Prediction of Post-Induction Hypotension in Cesarean Sections With Spinal Anesthesia
- Exparel vs. Marcaine ESP Block for Post-cardiac Surgical Pain (PHASE2, PHASE3)
- Comparison of M-TAPA and TAP Blocks on Postoperative Analgesia in Laparoscopic Inguinal Hernia Surgeries (NA)
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |