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Compound lidocaine
Compound lidocaine is a Local anesthetic Small molecule drug developed by Tianjin Medical University General Hospital. It is currently FDA-approved for Local anesthesia for infiltration, nerve blocks, and topical application, Pain relief in minor surgical and dental procedures. Also known as: Compound Lidocaine Hydrochloride Injection.
Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia.
Compound lidocaine is a small molecule that acts as a sodium channel alpha subunit blocker, classified as a blocker. It has been studied in various clinical trials for conditions such as knee osteoarthritis, vestibulodynia, temporomandibular disorder, fibromyalgia syndrome, and irritable bowel syndrome.
At a glance
| Generic name | Compound lidocaine |
|---|---|
| Also known as | Compound Lidocaine Hydrochloride Injection |
| Sponsor | Tianjin Medical University General Hospital |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Lidocaine is a local anesthetic that works by inhibiting sodium influx through voltage-gated sodium channels in the neuronal cell membrane. This prevents depolarization and the generation of action potentials, thereby blocking pain signal transmission along nerves. It is commonly used for infiltration anesthesia, nerve blocks, and topical anesthesia in clinical practice.
Approved indications
- Local anesthesia for infiltration, nerve blocks, and topical application
- Pain relief in minor surgical and dental procedures
Common side effects
- Injection site reactions (pain, erythema)
- Systemic toxicity (tremor, dizziness, seizures) at high doses
- Allergic reactions (rare with amide lidocaine)
- Methemoglobinemia (with topical spray formulations)
Key clinical trials
- Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments (PHASE2)
- Study Comparing Glycerin With 1% Lidocaine and Epinephrine Versus Glycerin With 1% Lidocaine Without Epinephrine for the Sclerotherapy of Leg Telangiectasias (PHASE4)
- Comparison of Compounded Topical Anesthetics (PHASE4)
- Comparing the Efficacy and Safety of Fractional Picosecond Laser and Gold Microneedle in the Treatment of Acne Scars (NA)
- Efficacy of Combined 1927nm Thulium Fiber Laser and Supramolecular Salicylic Acid in Photoaging Treatment (NA)
- EMLA Cream as Analgesic for Outpatient Gynecological Procedures (PHASE4)
- 35 kDa Hyaluronan Fragment (HA35) Reduces Chronic Inflammation of Skin (NA)
- Effects of Flourish HEC on Localized Provoked Vulvodynia (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Compound lidocaine CI brief — competitive landscape report
- Compound lidocaine updates RSS · CI watch RSS
- Tianjin Medical University General Hospital portfolio CI
Frequently asked questions about Compound lidocaine
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Related
- Drug class: All Local anesthetic drugs
- Target: All drugs targeting Voltage-gated sodium channels
- Manufacturer: Tianjin Medical University General Hospital — full pipeline
- Therapeutic area: All drugs in Anesthesia
- Indication: Drugs for Local anesthesia for infiltration, nerve blocks, and topical application
- Indication: Drugs for Pain relief in minor surgical and dental procedures
- Also known as: Compound Lidocaine Hydrochloride Injection
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing