{"id":"compound-lidocaine","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site reactions (pain, erythema)"},{"rate":null,"effect":"Systemic toxicity (tremor, dizziness, seizures) at high doses"},{"rate":null,"effect":"Allergic reactions (rare with amide lidocaine)"},{"rate":null,"effect":"Methemoglobinemia (with topical spray formulations)"}]},"_chembl":{"chemblId":"CHEMBL79","moleculeType":"Small molecule","molecularWeight":"234.34"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Lidocaine is a local anesthetic that works by inhibiting sodium influx through voltage-gated sodium channels in the neuronal cell membrane. This prevents depolarization and the generation of action potentials, thereby blocking pain signal transmission along nerves. It is commonly used for infiltration anesthesia, nerve blocks, and topical anesthesia in clinical practice.","oneSentence":"Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:30:53.510Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local anesthesia for infiltration, nerve blocks, and topical application"},{"name":"Pain relief in minor surgical and dental procedures"}]},"trialDetails":[{"nctId":"NCT03844412","phase":"PHASE2","title":"Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments","status":"COMPLETED","sponsor":"Duke University","startDate":"2019-11-04","conditions":"Vestibulodynia, Temporomandibular Disorder, Fibromyalgia Syndrome","enrollment":209},{"nctId":"NCT07342413","phase":"PHASE4","title":"Study Comparing Glycerin With 1% Lidocaine and Epinephrine Versus Glycerin With 1% Lidocaine Without Epinephrine for the Sclerotherapy of Leg Telangiectasias","status":"NOT_YET_RECRUITING","sponsor":"Goldman, Butterwick, Fitzpatrick and Groff","startDate":"2026-02-01","conditions":"Leg Veins","enrollment":20},{"nctId":"NCT06569537","phase":"PHASE4","title":"Comparison of Compounded Topical Anesthetics","status":"RECRUITING","sponsor":"Dartmouth-Hitchcock Medical Center","startDate":"2024-10-22","conditions":"Procedural Pain","enrollment":64},{"nctId":"NCT07078851","phase":"NA","title":"Comparing the Efficacy and Safety of Fractional Picosecond Laser and Gold Microneedle in the Treatment of Acne Scars","status":"COMPLETED","sponsor":"First Affiliated Hospital of Chongqing Medical University","startDate":"2023-09-01","conditions":"Acne Scarring, Acne Scars","enrollment":20},{"nctId":"NCT06925035","phase":"NA","title":"Efficacy of Combined 1927nm Thulium Fiber Laser and Supramolecular Salicylic Acid in Photoaging 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Morphine Gel for Pain Reduction in Patients With Cancer Wounds","status":"UNKNOWN","sponsor":"Instituto Nacional de Cancer, Brazil","startDate":"2023-09-12","conditions":"Wounds and Injuries, Cancer Pain, Cancer, Breast","enrollment":106},{"nctId":"NCT05964985","phase":"NA","title":"Effect of Quadratus Lumborum Block With Compound Lidocaine and Esketamine on Pain After Colorectal Surgery","status":"UNKNOWN","sponsor":"Tianjin Medical University General Hospital","startDate":"2023-08-06","conditions":"Postoperative Pain","enrollment":160},{"nctId":"NCT05127967","phase":"NA","title":"Consequences of Mutations in the SPG7 Gene at the Heterozygous State","status":"COMPLETED","sponsor":"University Hospital, Montpellier","startDate":"2021-11-16","conditions":"SPG7","enrollment":11},{"nctId":"NCT00716443","phase":"PHASE4","title":"Evaluate Efficacy, Safety & Subject Satisfaction of Pain Management With Pliaglis® Cream for Dermal Filler Injections","status":"TERMINATED","sponsor":"Galderma 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With Compound Lidocaine and Esketamine on Pain After Surgery","status":"UNKNOWN","sponsor":"Tianjin Medical University General Hospital","startDate":"2021-12-01","conditions":"Postoperative Pain","enrollment":160},{"nctId":"NCT04439786","phase":"PHASE4","title":"Intravenous Infusion of Lidocaine in Colonoscopy","status":"UNKNOWN","sponsor":"Shandong University","startDate":"2020-07-01","conditions":"Sedation","enrollment":50},{"nctId":"NCT04439773","phase":"PHASE4","title":"Intravenous Infusion of Lidocaine in Gastroscopy","status":"UNKNOWN","sponsor":"Shandong University","startDate":"2020-07-01","conditions":"Sedation","enrollment":130},{"nctId":"NCT03996577","phase":"PHASE4","title":"Intravenous Infusion of Lidocaine in ERCP","status":"UNKNOWN","sponsor":"Shandong University","startDate":"2019-05-15","conditions":"Sedation","enrollment":40},{"nctId":"NCT02572037","phase":"","title":"Research and Clinical Value of New Classification for Premature Ejaculation: Multi-Center 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Yat-Sen University","startDate":"2013-12","conditions":"Postoperative Agitation of Patients","enrollment":2000}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":32,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Compound Lidocaine Hydrochloride Injection"],"phase":"marketed","status":"active","brandName":"Compound lidocaine","genericName":"Compound lidocaine","companyName":"Tianjin Medical University General Hospital","companyId":"tianjin-medical-university-general-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Compound lidocaine is a small molecule that acts as a sodium channel alpha subunit blocker, classified as a blocker. It has been studied in various clinical trials for conditions such as knee osteoarthritis, vestibulodynia, temporomandibular disorder, fibromyalgia syndrome, and irritable bowel syndrome.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}