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Ropivacaine + Midazolam
Ropivacaine + Midazolam is a Local anesthetic + benzodiazepine combination Small molecule drug developed by Aga Khan University. It is currently FDA-approved for Local anesthesia with sedation for surgical and diagnostic procedures, Regional anesthesia with anxiolysis.
Ropivacaine blocks sodium channels to provide local anesthesia, while midazolam enhances sedation and anxiolysis through GABAergic receptor modulation.
Ropivacaine blocks sodium channels to provide local anesthesia, while midazolam enhances sedation and anxiolysis through GABAergic receptor modulation. Used for Local anesthesia with sedation for surgical and diagnostic procedures, Regional anesthesia with anxiolysis.
At a glance
| Generic name | Ropivacaine + Midazolam |
|---|---|
| Sponsor | Aga Khan University |
| Drug class | Local anesthetic + benzodiazepine combination |
| Target | Voltage-gated sodium channels (ropivacaine); GABA-A receptors (midazolam) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Pain Management |
| Phase | FDA-approved |
Mechanism of action
Ropivacaine is a long-acting amide local anesthetic that reversibly inhibits sodium influx in nerve fibers, preventing depolarization and conduction of action potentials. Midazolam is a benzodiazepine that potentiates inhibitory GABA signaling in the central nervous system, producing sedation, anxiolysis, and amnesia. Together, this combination provides both local pain control and systemic sedation for procedures.
Approved indications
- Local anesthesia with sedation for surgical and diagnostic procedures
- Regional anesthesia with anxiolysis
Common side effects
- Hypotension
- Respiratory depression
- Bradycardia
- Nausea
- Dizziness
- Injection site reactions
Key clinical trials
- Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy (NA)
- Comparing the QoR of PECS Block and GA in Breast-conserving Surgery With Sentinel Lymph Node Biopsy (NA)
- Sacral Canal Block for Hip Replacement the Efficacy and Safety of Controlled Intraoperative Hypotension (NA)
- Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair (PHASE4)
- Effect of New High Ankle Block on Wound Healing After the Operation of Debridement of Diabetes Foot (NA)
- Does Type of Anesthesia Influence Inflammation Change After Breast Surgery? (NA)
- The Application of Pectoral Nerve II(PECS II)block in Breast Fibroadenoma Resection Surgery (NA)
- Analgesic Efficacy of Ropivacaine Alone or in Combination With Adjuvants on Post-operative Analgesia Following Video-Assisted Thoracoscopic Surgery. (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ropivacaine + Midazolam CI brief — competitive landscape report
- Ropivacaine + Midazolam updates RSS · CI watch RSS
- Aga Khan University portfolio CI
Frequently asked questions about Ropivacaine + Midazolam
What is Ropivacaine + Midazolam?
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Who makes Ropivacaine + Midazolam?
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What does Ropivacaine + Midazolam target?
Related
- Drug class: All Local anesthetic + benzodiazepine combination drugs
- Target: All drugs targeting Voltage-gated sodium channels (ropivacaine); GABA-A receptors (midazolam)
- Manufacturer: Aga Khan University — full pipeline
- Therapeutic area: All drugs in Anesthesia/Pain Management
- Indication: Drugs for Local anesthesia with sedation for surgical and diagnostic procedures
- Indication: Drugs for Regional anesthesia with anxiolysis
- Compare: Ropivacaine + Midazolam vs similar drugs
- Pricing: Ropivacaine + Midazolam cost, discount & access