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Intraoperative Intravenous Lidocaine Infusion
Intraoperative Intravenous Lidocaine Infusion is a Local anesthetic / Sodium channel blocker Small molecule drug developed by McMaster University. It is currently in Phase 3 development for Perioperative pain management and opioid reduction in surgical patients, Postoperative recovery enhancement. Also known as: Xylocaine.
Lidocaine blocks sodium channels in nerve fibers, reducing pain signal transmission and providing local anesthetic and analgesic effects during surgery.
Lidocaine blocks sodium channels in nerve fibers, reducing pain signal transmission and providing local anesthetic and analgesic effects during surgery. Used for Perioperative pain management and opioid reduction in surgical patients, Postoperative recovery enhancement.
At a glance
| Generic name | Intraoperative Intravenous Lidocaine Infusion |
|---|---|
| Also known as | Xylocaine |
| Sponsor | McMaster University |
| Drug class | Local anesthetic / Sodium channel blocker |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Perioperative pain management / Surgery |
| Phase | Phase 3 |
Mechanism of action
Intravenous lidocaine infusion during surgery works by blocking voltage-gated sodium channels in peripheral nerves and the central nervous system, which suppresses pain signal conduction. This perioperative approach aims to reduce postoperative pain, opioid consumption, and potentially improve recovery outcomes. The mechanism also includes anti-inflammatory and immunomodulatory effects that may contribute to reduced surgical stress response.
Approved indications
- Perioperative pain management and opioid reduction in surgical patients
- Postoperative recovery enhancement
Common side effects
- Dizziness or lightheadedness
- Nausea
- Tinnitus
- Perioral numbness
- Cardiac arrhythmias (at high doses)
Key clinical trials
- Long-term Outcomes of Lidocaine Infusions for Post-Operative Pain (LOLIPOP) Trial (PHASE3)
- Intravenous Lidocaine Infusion in Lumbar Fusion Surgery (NA)
- Spinal Morphine or Intravenous Lidocaine in Robot-assisted Upper Urologic Surgery (PHASE3)
- Opioid-Free vs Opioid-Based Anesthesia for Nasal Surgeries (PHASE3)
- Intravenous Lidocaine, Ketamine, and Magnesium in Thoracic Surgery
- Erector Spinae Plane (ESP) Block vs Intravenous Lignocaine Infusion in (VATS) (NA)
- Comparison of the Effectiveness of Intraoperative Intravenous Lidocaine and Intravenous Remifentanil in Postoperative Pain Management in Laparoscopic Cholecystectomy
- LAPOFAR Trial: Opioid-Free vs. Remifentanil Anesthesia in Laparoscopic Cholecystectomy (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Intraoperative Intravenous Lidocaine Infusion CI brief — competitive landscape report
- Intraoperative Intravenous Lidocaine Infusion updates RSS · CI watch RSS
- McMaster University portfolio CI
Frequently asked questions about Intraoperative Intravenous Lidocaine Infusion
What is Intraoperative Intravenous Lidocaine Infusion?
How does Intraoperative Intravenous Lidocaine Infusion work?
What is Intraoperative Intravenous Lidocaine Infusion used for?
Who makes Intraoperative Intravenous Lidocaine Infusion?
Is Intraoperative Intravenous Lidocaine Infusion also known as anything else?
What drug class is Intraoperative Intravenous Lidocaine Infusion in?
What development phase is Intraoperative Intravenous Lidocaine Infusion in?
What are the side effects of Intraoperative Intravenous Lidocaine Infusion?
What does Intraoperative Intravenous Lidocaine Infusion target?
Related
- Drug class: All Local anesthetic / Sodium channel blocker drugs
- Target: All drugs targeting Voltage-gated sodium channels
- Manufacturer: McMaster University — full pipeline
- Therapeutic area: All drugs in Perioperative pain management / Surgery
- Indication: Drugs for Perioperative pain management and opioid reduction in surgical patients
- Indication: Drugs for Postoperative recovery enhancement
- Also known as: Xylocaine
- Compare: Intraoperative Intravenous Lidocaine Infusion vs similar drugs
- Pricing: Intraoperative Intravenous Lidocaine Infusion cost, discount & access