{"id":"intraoperative-intravenous-lidocaine-infusion","safety":{"commonSideEffects":[{"rate":null,"effect":"Dizziness or lightheadedness"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Tinnitus"},{"rate":null,"effect":"Perioral numbness"},{"rate":null,"effect":"Cardiac arrhythmias (at high doses)"}]},"_chembl":{"chemblId":"CHEMBL79","moleculeType":"Small molecule","molecularWeight":"234.34"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Intravenous lidocaine infusion during surgery works by blocking voltage-gated sodium channels in peripheral nerves and the central nervous system, which suppresses pain signal conduction. This perioperative approach aims to reduce postoperative pain, opioid consumption, and potentially improve recovery outcomes. The mechanism also includes anti-inflammatory and immunomodulatory effects that may contribute to reduced surgical stress response.","oneSentence":"Lidocaine blocks sodium channels in nerve fibers, reducing pain signal transmission and providing local anesthetic and analgesic effects during surgery.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:16:40.671Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Perioperative pain management and opioid reduction in surgical patients"},{"name":"Postoperative recovery enhancement"}]},"trialDetails":[{"nctId":"NCT05072314","phase":"PHASE3","title":"Long-term Outcomes of Lidocaine Infusions for Post-Operative Pain (LOLIPOP) Trial","status":"RECRUITING","sponsor":"Monash University","startDate":"2022-07-27","conditions":"Breast Cancer, Breast Cancer Female, Breast Conserving Surgery","enrollment":4300},{"nctId":"NCT07488832","phase":"NA","title":"Intravenous Lidocaine Infusion in Lumbar Fusion 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