Bupivacaine Liposomes(BL) — Competitive Intelligence Brief

Bupivacaine Liposomes(BL) (Bupivacaine Liposomes(BL)) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Local anesthetic (liposomal formulation). Area: Anesthesia/Pain Management.

marketed Local anesthetic (liposomal formulation) Voltage-gated sodium channels Anesthesia/Pain Management Small molecule

Target snapshot

Bupivacaine Liposomes(BL) (Bupivacaine Liposomes(BL)) — Huazhong University of Science and Technology. Bupivacaine liposomes is a long-acting local anesthetic formulation that delivers bupivacaine encapsulated in lipid vesicles to provide prolonged nerve blockade and pain relief.

Comparator set (6 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Bupivacaine Liposomes(BL) TARGET	Bupivacaine Liposomes(BL)	Huazhong University of Science and Technology	marketed	Local anesthetic (liposomal formulation)	Voltage-gated sodium channels
Venlafaxine and Lamotrigine	Venlafaxine and Lamotrigine	University Health Network, Toronto	marketed	SNRI + anticonvulsant combination	Serotonin transporter, norepinephrine transporter, voltage-gated sodium channels, glutamate modulation
Multiple injection local anesthetic	Multiple injection local anesthetic	Hôpital du Valais	marketed	Local anesthetic	Voltage-gated sodium channels
Depofoam bupivacaine	Depofoam bupivacaine	The Cleveland Clinic	marketed	Local anesthetic (liposomal formulation)	Voltage-gated sodium channels
intravenous saline plus perineural bupivacaine	intravenous saline plus perineural bupivacaine	Sherif Mohamed Abd el moneim Soaida, MD	marketed	Local anesthetic with supportive fluid therapy	Voltage-gated sodium channels (Nav)
Hyperbaric Bupivicaine	Hyperbaric Bupivicaine	University of Witwatersrand, South Africa	marketed	Local anesthetic (amide)	Voltage-gated sodium channels
tetracaine HCl and oxymetazoline HCL	tetracaine HCl and oxymetazoline HCL	Louisiana State University Health Sciences Center in New Orleans	marketed	Local anesthetic with vasoconstrictor combination	Voltage-gated sodium channels (tetracaine); alpha-2 adrenergic receptors (oxymetazoline)

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Local anesthetic (liposomal formulation) class)

1. Pacira Pharmaceuticals, Inc · 4 drugs in this class
2. Huazhong University of Science and Technology · 1 drug in this class
3. Maimonides Medical Center · 1 drug in this class
4. The Cleveland Clinic · 1 drug in this class
5. The Cooper Health System · 1 drug in this class
6. The University of Texas Health Science Center, Houston · 1 drug in this class
7. Tianjin Medical University General Hospital · 1 drug in this class
8. University of California, Davis · 1 drug in this class
9. Catherine Vandepitte, M.D. · 1 drug in this class
10. Wake Forest University Health Sciences · 1 drug in this class