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Hyperbaric Bupivicaine
Hyperbaric Bupivicaine is a Local anesthetic (amide) Small molecule drug developed by University of Witwatersrand, South Africa. It is currently FDA-approved for Spinal anesthesia for surgical procedures, Regional anesthesia and analgesia. Also known as: Spinal Bupivicaine, Bupivacaine, hyperbaric bupivacaine.
Hyperbaric bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials to produce regional anesthesia.
Hyperbaric Bupivacaine is a small molecule that acts as a sodium channel protein type IV alpha subunit blocker, classified as a blocker. It is used in subarachnoid anesthesia for conditions such as hip fracture and postoperative complications, often in combination with other agents like dexmedetomidine.
At a glance
| Generic name | Hyperbaric Bupivicaine |
|---|---|
| Also known as | Spinal Bupivicaine, Bupivacaine, hyperbaric bupivacaine |
| Sponsor | University of Witwatersrand, South Africa |
| Drug class | Local anesthetic (amide) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine is an amide-type local anesthetic that reversibly inhibits sodium influx into nerve fibers, thereby preventing depolarization and nerve impulse transmission. The hyperbaric formulation (made hypertonic with dextrose) increases the density of the solution, allowing it to settle dependently in the cerebrospinal fluid when used for spinal anesthesia, providing predictable distribution and duration of action.
Approved indications
- Spinal anesthesia for surgical procedures
- Regional anesthesia and analgesia
Common side effects
- Hypotension
- Bradycardia
- Headache (post-dural puncture)
- Neurological toxicity (at high doses)
- Cardiovascular toxicity (at high doses)
Key clinical trials
- Comparison of Intrathecal Bupivacaine With and Without Morphine for Post-operative Analgesia in Parturients Undergoing Elective Cesarean Section: A Randomized Controlled Trial (PHASE4)
- Comparative Study of Fentanyl vs Dexmedetomidine as Adjuvants to Intrathecal Bupivacaine in Cesarean Section (NA)
- Role of Dexmedetomidine as Synergistic Agent (PHASE2, PHASE3)
- Erector Spinae Plane Block for Postoperative Pain Control in Hip Replacement Surgeries (NA)
- A Trial To Assess Risk of Delirium in Older Adults Undergoing Hip Fracture Surgery With Spinal or General Anesthesia (NA)
- Dexmedetomidine for Sedation in Total Knee Replacements (PHASE3)
- Intrathecal Opioid Study (PHASE4)
- ET 50 for Post Caesarean Section Spinal Hypotension (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Hyperbaric Bupivicaine CI brief — competitive landscape report
- Hyperbaric Bupivicaine updates RSS · CI watch RSS
- University of Witwatersrand, South Africa portfolio CI
Frequently asked questions about Hyperbaric Bupivicaine
What is Hyperbaric Bupivicaine?
How does Hyperbaric Bupivicaine work?
What is Hyperbaric Bupivicaine used for?
Who makes Hyperbaric Bupivicaine?
Is Hyperbaric Bupivicaine also known as anything else?
What drug class is Hyperbaric Bupivicaine in?
What development phase is Hyperbaric Bupivicaine in?
What are the side effects of Hyperbaric Bupivicaine?
What does Hyperbaric Bupivicaine target?
Related
- Drug class: All Local anesthetic (amide) drugs
- Target: All drugs targeting Voltage-gated sodium channels
- Manufacturer: University of Witwatersrand, South Africa — full pipeline
- Therapeutic area: All drugs in Anesthesia
- Indication: Drugs for Spinal anesthesia for surgical procedures
- Indication: Drugs for Regional anesthesia and analgesia
- Also known as: Spinal Bupivicaine, Bupivacaine, hyperbaric bupivacaine
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing