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Multiple injection local anesthetic
Local anesthetics block sodium channels in nerve fibers, preventing the initiation and propagation of action potentials to produce localized numbness and pain relief.
Local anesthetics block sodium channels in nerve fibers to prevent the initiation and propagation of action potentials, thereby producing reversible loss of sensation in a localized area. Used for Local anesthesia for minor surgical procedures, Local anesthesia for dental procedures, Local anesthesia for pain management.
At a glance
| Generic name | Multiple injection local anesthetic |
|---|---|
| Sponsor | Hôpital du Valais |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Local anesthetics reversibly inhibit sodium influx through voltage-gated sodium channels in nerve cell membranes, thereby preventing depolarization and nerve impulse transmission in the injected area. This effect is localized to the site of injection and surrounding tissues, producing anesthesia without systemic effects when used appropriately. Multiple injections allow for extended anesthetic coverage across a larger anatomical region.
Approved indications
- Local and regional anesthesia for surgical and procedural pain control
Common side effects
- Injection site pain or discomfort
- Transient numbness or paresthesia
- Allergic reaction (rare, agent-dependent)
- Systemic toxicity (if overdosed or intravascular injection)
Key clinical trials
- Parascapular Sub Iliocostalis Plane Block Versus Thoracic Paravertebral Plane Block for Traumatic Multiple Rib Fractures (NA)
- A Study of the Treatment of Recurrent Malignant Glioma With rQNestin34.5v.2 (PHASE1)
- A Superiority Trial of Radiofrequency Ablation for Low Back Pain (NA)
- "The Importance of Adding Fenestration to Ultrasound-Guided Baker's Cyst Aspiration" (NA)
- Erector Spinae Plane Block Versus Quadratus Lumborum Block (NA)
- VibraCool Device to Reduce Pain and Opioid Use After Anterior Cruciate Ligament Reconstruction (ACLR) (NA)
- The Analgesic Effect of Retro-laminar Block Versus Paravertebral Block in Patients With Multiple Fracture Ribs (NA)
- Combination Versus Alone Liposomal Bupivacaine Blocks in Minimally Invasive Thoracic Surgery-1 (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Multiple injection local anesthetic CI brief — competitive landscape report
- Multiple injection local anesthetic updates RSS · CI watch RSS
- Hôpital du Valais portfolio CI