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tetracaine HCl and oxymetazoline HCL
tetracaine HCl and oxymetazoline HCL is a Local anesthetic with vasoconstrictor combination Small molecule drug developed by Louisiana State University Health Sciences Center in New Orleans. It is currently FDA-approved for Topical anesthesia and hemostasis for nasal surgery and procedures.
This combination drug provides local anesthesia via tetracaine and nasal vasoconstriction via oxymetazoline to reduce bleeding and improve surgical visibility in nasal procedures.
This combination drug provides local anesthesia via tetracaine and nasal vasoconstriction via oxymetazoline to reduce bleeding and improve surgical visibility in nasal procedures. Used for Topical anesthesia and hemostasis for nasal surgery and procedures.
At a glance
| Generic name | tetracaine HCl and oxymetazoline HCL |
|---|---|
| Sponsor | Louisiana State University Health Sciences Center in New Orleans |
| Drug class | Local anesthetic with vasoconstrictor combination |
| Target | Voltage-gated sodium channels (tetracaine); alpha-2 adrenergic receptors (oxymetazoline) |
| Modality | Small molecule |
| Therapeutic area | Otolaryngology / Surgery |
| Phase | FDA-approved |
Mechanism of action
Tetracaine is a local anesthetic that blocks sodium channels in nerve membranes, preventing pain signal transmission in nasal tissues. Oxymetazoline is an alpha-2 adrenergic agonist that causes vasoconstriction of blood vessels in the nasal mucosa, reducing bleeding and edema during surgical procedures. Together, they provide both anesthesia and hemostasis for nasal surgery.
Approved indications
- Topical anesthesia and hemostasis for nasal surgery and procedures
Common side effects
- Local irritation or burning
- Transient nasal congestion rebound
- Headache
- Systemic sympathomimetic effects (with excessive absorption)
Key clinical trials
- Clinical Evaluation of no Needle Dental Anesthesia Compared to Syringe Anesthesia Delivery (EARLY_PHASE1)
- Efficacy of Tetracaine/Oxymetazoline Nasal Spray for Endodontic Treatment (PHASE4)
- : Pulpal Blood Flow With the Use of Intra-nasal Anesthetic (PHASE4)
- Comparison of Intranasal Kovacaine Mist, Tetracaine Alone, and Placebo for Anesthetizing Maxillary Teeth (PHASE3)
- Dose-Escalation Safety and Pharmacokinetic Study of K305 (PHASE2)
- Dose-Ranging Study of Intranasal Kovacaine Mist in Pediatric Subjects (PHASE2)
- Comparison of Intranasal Kovacaine Mist, Tetracaine Alone, and Placebo for Anesthetizing Maxillary Teeth in Adults (PHASE3)
- Comparison of Intranasal Kovacaine Mist, and Placebo for Anesthetizing Maxillary Teeth in Pediatric Patients (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
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- Louisiana State University Health Sciences Center in New Orleans portfolio CI
Frequently asked questions about tetracaine HCl and oxymetazoline HCL
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Related
- Drug class: All Local anesthetic with vasoconstrictor combination drugs
- Target: All drugs targeting Voltage-gated sodium channels (tetracaine); alpha-2 adrenergic receptors (oxymetazoline)
- Manufacturer: Louisiana State University Health Sciences Center in New Orleans — full pipeline
- Therapeutic area: All drugs in Otolaryngology / Surgery
- Indication: Drugs for Topical anesthesia and hemostasis for nasal surgery and procedures
- Compare: tetracaine HCl and oxymetazoline HCL vs similar drugs
- Pricing: tetracaine HCl and oxymetazoline HCL cost, discount & access