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Efficacy of Tetracaine/Oxymetazoline Nasal Spray for Endodontic Treatment
Purpose: To evaluate anesthetic efficacy and overall patient experience with use of Kovanaze tetracaine/oxymetazoline nasal spray for root canal treatment of vital premolar and anterior teeth needing root canal treatment. Participants: 30 adult patients with a vital upper anterior or premolar tooth (#4-13) with a diagnosis indicating need root canal treatment and who are seeking treatment in the UNC Chapel Hill School of Dentistry. Procedures (methods): Qualifying patients will be anesthetized with tetracaine/oxymetazoline nasal spray anesthetic in order to facilitate completion of their clinically required, standard of care root canal treatment. Research procedures include blood pressure monitoring and pain assessment using a visual analogue pain scale.
Details
| Lead sponsor | University of North Carolina, Chapel Hill |
|---|---|
| Phase | Phase 4 |
| Status | WITHDRAWN |
| Start date | 2018-09 |
| Completion | 2019-07 |
Conditions
- Endodontic Disease
- Endodontic Inflammation
- Local Anesthesia
- Dental Anesthesia
Interventions
- Tetracaine HCl and oxymetazoline HCl nasal spray
Primary outcomes
- Proportion of patients that are successfully anesthetized for endodontic treatment — From beginning to end of endodontic treatment appointment (about 1 to 1.5 hours)
Anesthetic success is defined as having sufficiently anesthetize teeth to allow for endodontic treatment.