Last reviewed · How we verify
NCT06733168: PEEP
The Impact of PEEP-guided Electrical Impedance Tomography on Oxygenation and Pulmonary Mechanics in Moderate-to-severe ARDS
NA trial testing electrical impedance tomography in Acute Respiratory Syndrome Distress in 76 participants. Currently enrolling.
15 December 2026
Quick facts
| Lead sponsor | Vietnam Military Medical University |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 76 |
| Start date | 15 August 2024 |
| Primary completion | 15 December 2026 |
| Estimated completion | 30 December 2026 |
| Sites | 1 location across Vietnam |
Drugs / interventions tested
- electrical impedance tomography
- Non-EIT
Conditions studied
- Acute Respiratory Syndrome Distress — all drugs for Acute Respiratory Syndrome Distress →
- Positive End-Expiratory Pressure — all drugs for Positive End-Expiratory Pressure →
- Mechanical Ventilation — all drugs for Mechanical Ventilation →
- Electrical Impedance Tomography (EIT) — all drugs for Electrical Impedance Tomography (EIT) →
Sponsor
Vietnam Military Medical University
Who can join
18 and older, any sex, with Acute Respiratory Syndrome Distress or Positive End-Expiratory Pressure. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Acute respiratory distress syndrome (ARDS) in its moderate to severe forms is associated with high mortality. Mechanical ventilation (MV) remains the cornerstone of ARDS management but carries a significant risk of ventilator-induced lung injury (VILI). Positive end-expiratory pressure (PEEP), a fundamental component of MV, is widely utilized in clinical practice; however, optimal PEEP selection for patients with moderate to severe ARDS remains a complex and unresolved challenge. Electrical impedance tomography (EIT), a bedside imaging modality that evaluates regional ventilation distribution, offers a means of individualizing PEEP settings in mechanically ventilated patients. By balancing the competing risks of alveolar overdistension and collapse, EIT facilitates precision in PEEP titration. This study compares the impact of EIT-guided PEEP selection versus the conventional low FiO2-PEEP table on blood oxygenation and pulmonary mechanics.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
The impact of PEEP-guided electrical impedance tomography on oxygenation and respiratory mechanics in moderate-to-severe ARDS: a randomized controlled trial.
Van Trung D, Giang BTH, Tuan DQ, Tan NC, et al · · 2025 · cited 1× · PMID 41318662 · DOI 10.1038/s41598-025-29787-5
Verify or expand the search:
- PubMed search for NCT06733168
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of electrical impedance tomography
Trials testing the same drug.
- NCT06876792 — Electrical Impedance Tomography-derived Flow Index During Spontaneous Breathing Trial Stratifies the Risk of Reintubatio · completed
- NCT06850844 — Recruitment Maneuvers and PEEP-guided Electrical Impedance Tomography for Abdominal Laparoscopic Surgery Patients · NA · recruiting
- NCT06481124 — End-expiratory Pressure During Laparoscopic Surgery in the Trendelenburg Position by Electrical Impedance Tomography · completed
- NCT05207202 — Effect of EIT-guided PEEP Titration on the Prognosis of Patients with Moderate to Severe ARDS · NA · completed
Other recruiting trials for Acute Respiratory Syndrome Distress
Currently open trials in the same condition.
- NCT07313644 — EIT-Guided PEEP Optimization in Trauma and Postoperative ARDS · NA · recruiting
Other Vietnam Military Medical University trials
Trials by the same sponsor.
- NCT04384016 — Safety and Immunogenicity of Skyvaricella Injection in Healthy Volunteer Vietnamese Children From 12 Months to 12 Years · Phase 4 · completed
- NCT04695717 — This Study Was Conducted to Evaluate the Safety and Immunogenicity of IVACFLU-S Produced in Children From 6 Months to Un · Phase 3 · completed
- NCT05937113 — Safety and Immunogenicity of the Inactivated Rabies Vaccine RABIVAX-S Administered Intramuscularly and Intradermally · Phase 4 · completed
- NCT04546932 — Lung-protective Mechanical Ventilation for Abdominal Laparoscopic Surgeries · NA · completed
- NCT06042816 — Analgesic Efficacy of Free-opioid Anesthesia for Colorectal Surgery · NA · completed
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06733168 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Vietnam Military Medical University
- Last refreshed: 13 December 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06733168.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing