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NCT06876792: EIT-FI Weaning
Electrical Impedance Tomography-derived Flow Index During Spontaneous Breathing Trial Stratifies the Risk of Reintubation Within 48 h After Extubation: A Multicenter Prospective Observational Study
trial testing electrical impedance tomography in Acute Respiratory Failure in 150 participants. Completed in 31 December 2025.
31 December 2025
Quick facts
| Lead sponsor | Ruijin Hospital |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 150 |
| Start date | 1 December 2024 |
| Primary completion | 31 December 2025 |
| Estimated completion | 31 December 2025 |
| Sites | 3 locations across China |
Drugs / interventions tested
- electrical impedance tomography
Conditions studied
- Acute Respiratory Failure — all drugs for Acute Respiratory Failure →
- Ventilator Weaning Assessment — all drugs for Ventilator Weaning Assessment →
Sponsor
Ruijin Hospital
Who can join
Adults 18 to 90, any sex, with Acute Respiratory Failure or Ventilator Weaning Assessment. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Accurate prediction of readiness to liberate patients from mechanical ventilation remains challenging. Conventional indices such as the rapid shallow breathing index (RSBI) and maximal inspiratory pressure (MIP) often miss early signs of injurious breathing patterns or regional ventilation asynchrony that can lead to extubation failure. Electrical impedance tomography (EIT) provides continuous, non-invasive imaging of regional lung ventilation. We developed a novel EIT-derived Flow Index (FI) which integrates the magnitude of inspiratory effort with the temporal synchrony of lung filling. This prospective, multicenter observational study aimed to (1) validate the predictive value of FI during spontaneous breathing trials (SBT) compared with conventional weaning indices, and (2) compare the predictive ability of EFI with traditional weaning indices(RSBI,MIP,P0.1).
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Electrical impedance tomography-derived flow index during spontaneous breathing trial stratifies the risk of reintubation within 48 h after extubation.
Zhang R, Xu J, Wu J, Tan R, et al · · 2026 · PMID 42219497 · DOI 10.1186/s13054-026-06098-3
Verify or expand the search:
- PubMed search for NCT06876792
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Currently open trials in the same condition.
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Other Ruijin Hospital trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06876792 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Ruijin Hospital
- Last refreshed: 13 April 2026
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