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NCT05207202
Effect of EIT-guided PEEP Titration on the Prognosis of Patients with Moderate to Severe ARDS
NA trial testing electrical impedance tomography in Clinical Outcomes in 190 participants. Completed in 20 July 2023.
20 July 2023
Quick facts
| Lead sponsor | Southeast University, China |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | sequential |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 190 |
| Start date | 20 February 2022 |
| Primary completion | 20 July 2023 |
| Estimated completion | 20 July 2023 |
| Sites | 5 locations across China |
Drugs / interventions tested
- electrical impedance tomography
Conditions studied
- Clinical Outcomes — all drugs for Clinical Outcomes →
Sponsor
Southeast University, China
Who can join
Adults 18 to 80, any sex, with Clinical Outcomes. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Acute respiratory syndrome distress (ARDS) is a clinical common syndrome with high mortality. Mechanical ventilation (MV) is the cornerstone of management of ARDS but can lead to ventilator-induced lung injury. Positive end-expiratory pressure (PEEP), as one of main component of MV, has been widely used in the clinical practice. However, the PEEP selection is still a difficult problem for moderate to severe ARDS patients. EIT, an imaging tool evaluating the regional ventilation distribution at the bedside, can achieve the individual PEEP selection for all mechanically ventilated patients. This article compared the effect of PEEP titrated guided by EIT with fraction of inspired oxygen (FiO2)-PEEP table on the clinical outcomes.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Effect of EIT-guided PEEP titration on prognosis of patients with moderate to severe ARDS: study protocol for a multicenter randomized controlled trial.
Yuan X, Zhang R, Wang Y, Chen D, et al · · 2023 · cited 7× · PMID 37041561 · DOI 10.1186/s13063-023-07280-6 -
Electrical impedance tomography-guided positive end-expiratory pressure and mortality of patients with the acute respiratory distress syndrome: the EITVent randomized clinical trial.
Yuan X, Zhong M, Li Z, Sang L, et al · · 2026 · cited 1× · PMID 41738148 · DOI 10.1093/ajrccm/aamaf125
Verify or expand the search:
- PubMed search for NCT05207202
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Southeast University, China trials
Trials by the same sponsor.
- NCT07519512 — Effect of Early Transition to Assisted Ventilation on 28-day Successful Extubation in Critically Ill Patients · NA · recruiting
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- NCT07362537 — Enteral Nutrition Delivery in Prone Position Ventilated Patients With Moderate to Severe ARDS · NA · recruiting
- NCT07327268 — Cyclic On-off Switching of Pulmonary Blood Flow in Moderate to Severe ARDS · not yet recruiting
- NCT07284888 — Practices of Prone Positioning Ventilation in Patients With Moderate-to-Severe ARDS in Intensive Care Units: A Registry- · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05207202 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Southeast University, China
- Last refreshed: 20 March 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05207202.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing