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NCT06990477
Effect of EIT-guided PEEP in ARDS Patients With Higher Recruitability
NA trial testing EIT-guided PEEP in ARDS (Acute Respiratory Distress Syndrome) in 264 participants. Currently enrolling.
19 January 2029
Quick facts
| Lead sponsor | Southeast University, China |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 264 |
| Start date | 28 January 2026 |
| Primary completion | 19 January 2029 |
| Estimated completion | 20 February 2029 |
| Sites | 3 locations across China |
Drugs / interventions tested
- EIT-guided PEEP
Conditions studied
- ARDS (Acute Respiratory Distress Syndrome) — all drugs for ARDS (Acute Respiratory Distress Syndrome) →
Sponsor
Southeast University, China
Who can join
Adults 19 to 85, any sex, with ARDS (Acute Respiratory Distress Syndrome). Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Acute respiratory syndrome distress (ARDS) is a clinical common syndrome with high mortality. Mechanical ventilation (MV) is the cornerstone of management of ARDS but can lead to ventilator-induced lung injury. Positive end-expiratory pressure (PEEP), as one of main component of MV, has been widely used in the clinical practice. However, the PEEP selection is still a difficult problem for moderate to severe ARDS patients. EIT, an imaging tool evaluating the regional ventilation distribution at the bedside, can achieve the individual PEEP selection for all mechanically ventilated patients. Our previous study found that moderate to severe ARDS patients with higher recruitability could benefit from EIT-guided PEEP. This article compared the effect of PEEP titrated guided by EIT with fraction of inspired oxygen (FiO2)-PEEP table on the clinical outcomes in patients with higher recruitability.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06990477
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Related trials
Other trials of EIT-guided PEEP
Trials testing the same drug.
- NCT05307913 — PET - PEEP by EIT for Acute Respiratory Distress Syndrome Trial · NA · completed
Other recruiting trials for ARDS (Acute Respiratory Distress Syndrome)
Currently open trials in the same condition.
- NCT07125079 — Lung Injury is One of the Primary Causes of Morbidity and Mortality in Critically Ill Patients. These Patients Will be M · recruiting
- NCT06911450 — Pleural Strain by Speckle-Tracking Ultrasound: Feasibility and Driving Pressure Associations · recruiting
- NCT06734988 — EXTEND ARDS-J Esophageal Pressure Study · recruiting
- NCT06790875 — Effects of Low Tidal Volume and Airway Pressure Release Ventilation on Lung Tissue Mechanics in ARDS Patients Under Mech · NA · recruiting
- NCT07083973 — Prone Position Assessed by 3D EIT · recruiting
Other Southeast University, China trials
Trials by the same sponsor.
- NCT07519512 — Effect of Early Transition to Assisted Ventilation on 28-day Successful Extubation in Critically Ill Patients · NA · recruiting
- NCT07362537 — Enteral Nutrition Delivery in Prone Position Ventilated Patients With Moderate to Severe ARDS · NA · recruiting
- NCT07284888 — Practices of Prone Positioning Ventilation in Patients With Moderate-to-Severe ARDS in Intensive Care Units: A Registry- · recruiting
- NCT07327268 — Cyclic On-off Switching of Pulmonary Blood Flow in Moderate to Severe ARDS · not yet recruiting
- NCT07289711 — Validation and Precision Treatment of Inflammatory Subphenotypes in Acute Respiratory Distress Syndrome: A Multicenter C · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06990477 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Southeast University, China
- Last refreshed: 2 February 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06990477.
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