NCT04546932

Lung-protective Mechanical Ventilation for Abdominal Laparoscopic Surgeries

Completed NA Last updated 14 September 2020

What this trial tests

NA trial testing Lung-protective mechanical ventilation in Mechanical Ventilation Complication in 62 participants. Completed in 24 June 2020.

Timeline

15 January 2020

Primary endpoint
24 June 2020

24 June 2020

Quick facts

Lead sponsor	Vietnam Military Medical University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	prevention
Enrollment	62
Start date	15 January 2020
Primary completion	24 June 2020
Estimated completion	24 June 2020
Sites	1 location across Vietnam

Drugs / interventions tested

• Lung-protective mechanical ventilation

Conditions studied

• Mechanical Ventilation Complication — all drugs for Mechanical Ventilation Complication →

Sponsor

Vietnam Military Medical University

Who can join

18 and older, any sex, with Mechanical Ventilation Complication. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This was a double-blind, randomized controlled clinical trial. 62 patients were randomly assigned to receive either lung-protective ventilation (LPV) with a tidal volume (Vt) of 7 ml/kg ideal body weight (IBW), 10 cmH2O positive end-expiratory pressure (PEEP) combined with regular recruitment maneuvers or conventional ventilation (CV) with a Vt of 10 ml/kg IBW, 0 cmH2O in PEEP and no recruitment maneuvers. The primary endpoints were the intraoperative fluctuation of Cdyn and Cstat, the intra- and postoperative changes in pulmonary oxygenation function including OI, A-aO2. The secondary endpoints were the alteration on chest x-ray, modified Clinical Pulmonary Infection Score (mCPIS), and the incidence of PPCs on the first postoperative day

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Lung-protective mechanical ventilation for patients undergoing abdominal laparoscopic surgeries: a randomized controlled trial.
   Nguyen TK, Nguyen VL, Nguyen TG, Mai DH, et al · · 2021 · cited 25× · PMID 33784987 · DOI 10.1186/s12871-021-01318-5