NCT06668337 is a Phase 4 clinical trial of Ephedrine in Hypotension After Spinal Anesthesia, sponsored by B.P. Koirala Institute of Health Sciences.

Who is sponsoring NCT06668337?

NCT06668337 is sponsored by B.P. Koirala Institute of Health Sciences.

What drugs are being tested in NCT06668337?

Interventions in NCT06668337: Normal Saline (Placebo), Ephedrine, Ephedrine.

What condition does NCT06668337 study?

NCT06668337 studies Hypotension After Spinal Anesthesia, Hypotension During Cesarean Delivery.

Is NCT06668337 still recruiting?

NCT06668337 is currently completed. Last updated 31 October 2024.

Last reviewed 2024-10-31 · How we verify

NCT06668337

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Ephedrine Doses to Prevent Maternal Hypotension After Spinal Anesthesia in Cesarean Section

Completed Phase 4 Last updated 31 October 2024

What this trial tests

Phase 4 trial testing Normal Saline (Placebo) in Hypotension After Spinal Anesthesia in 120 participants. Completed in 15 February 2022.

Timeline

1 August 2020

Primary endpoint
1 August 2021

15 February 2022

Quick facts

Lead sponsor	B.P. Koirala Institute of Health Sciences
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	120
Start date	1 August 2020
Primary completion	1 August 2021
Estimated completion	15 February 2022
Sites	1 location across Nepal

Drugs / interventions tested

Normal Saline (Placebo) — full drug profile →
Ephedrine (EPHEDRINE) — full drug profile →
Ephedrine (EPHEDRINE) — full drug profile →

Conditions studied

Hypotension After Spinal Anesthesia — all drugs for Hypotension After Spinal Anesthesia →
Hypotension During Cesarean Delivery — all drugs for Hypotension During Cesarean Delivery →

Sponsor

B.P. Koirala Institute of Health Sciences

Who can join

Adults 18 to 40, female only, with Hypotension After Spinal Anesthesia or Hypotension During Cesarean Delivery. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This randomized controlled trial aims to compare the effectiveness of different doses of ephedrine infusion in preventing maternal hypotension following spinal anesthesia in parturients undergoing cesarean sections. The study includes 120 participants, aged 18-40 years, with American Society of Anesthesiologists (ASA) physical status II, who are scheduled for elective cesarean delivery. The primary objective is to determine whether low-dose ephedrine infusions at 1.25 mg/min or 1.5 mg/min effectively reduce the incidence of maternal hypotension, with secondary outcomes assessing the need for rescue ephedrine, incidence of side effects (nausea, vomiting, tachycardia), and neonatal Apgar scores. Researchers will compare three groups-saline, 1.25 mg/min ephedrine, and 1.5 mg/min ephedrine-to evaluate their impact on maternal hemodynamic stability.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other trials of Ephedrine

Trials testing the same drug.

NCT06921473 — Effect of Ephedrine vs. Norepinephrine on Prevention of Fetal Acidosis During Cesarean Section Under Spinal Anesthesia · Phase 4 · completed
NCT06844201 — Postoperative Delirium After Intraoperative Ephedrine Versus Norepinephrine · not yet recruiting
NCT06741410 — Ephedrine Versus Phenylephrine for Spinal Block - Related Hypotension in Cesarean Delivery · completed
NCT06498076 — Management of Postspinal Anesthesia Hypotension During Elective Cesarean Section: Baby Norepinephrine Versus Ephedrine · NA · recruiting
NCT07034911 — Ketamine vs Ephedrine on Post Spinal Hypotension in Caesarean Delivery · Phase 1 · completed

Other recruiting trials for Hypotension After Spinal Anesthesia

Currently open trials in the same condition.

NCT07037654 — Lingual Ondansetron in Reduction of Spinal Hypotension in Cesarean Section · NA · active not recruiting

Other B.P. Koirala Institute of Health Sciences trials

Trials by the same sponsor.

NCT07285447 — Re-use of Ambu aScope During Exploration of the Common Bile Duct for Stones in Low-Resource Settings- a Retrospective St · completed
NCT06713733 — Comparison of Clinical Efficacy of Submucosal Dexamethasone and Oral Trypsin-chymotrypsin for Reduction of Postoperative · NA · recruiting
NCT07003581 — Cardiometabolic Risk Factors Associated With Multidrug-Resistant Tuberculosis · completed
NCT06146491 — A COMPARISON OF TRANSDERMAL DICLOFENAC AND ORAL COMBINATION OF PARACETAMOL AND IBUPROFEN IN POSTOPERATIVE PAIN MANAGEMEN · Phase 4 · unknown
NCT07378462 — A Retrospective Randomized Controlled Study Comparing the Effectiveness of Low-level Laser Therapy and Ultrasound Therap · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06668337 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by B.P. Koirala Institute of Health Sciences
Last refreshed: 31 October 2024

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06668337.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing