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Akovaz (EPHEDRINE)
Akovaz works by releasing norepinephrine, a natural chemical in the body that helps to relieve symptoms of respiratory and allergic conditions.
At a glance
| Generic name | EPHEDRINE |
|---|---|
| Sponsor | Nexus |
| Drug class | Norepinephrine Releasing Agent |
| Target | Beta-2 adrenergic receptor |
| Modality | Small molecule |
| Therapeutic area | Infectious Disease |
| Phase | FDA-approved |
| First approval | 2016 |
Mechanism of action
Ephedrine sulfate is sympathomimetic amine that directly acts as an agonist at and ss-adrenergic receptors and indirectly causes the release of norepinephrine from sympathetic neurons. Pressor effects by direct alpha- and beta-adrenergic receptor activation are mediated by increases in arterial pressures, cardiac output, and peripheral resistance. Indirect adrenergic stimulation is caused by norepinephrine release from sympathetic nerves.
Approved indications
- Allergic conjunctivitis
- Allergic rhinitis
- Bronchitis
- Bronchospasm
- Common cold
- Headache disorder
- Influenza-like symptoms
- Nasal congestion
- Nasal discharge
- Rhinitis
- Seasonal allergic rhinitis
- Sinus headache
- Sneezing
- Vasomotor rhinitis
Common side effects
- nervousness
- insomnia
- vertigo
- headache
- tachycardia
- palpitation
- sweating
- nausea
- vomiting
- anorexia
- vesical sphincter spasm
- difficult and painful urination
Drug interactions
- Inhalational Anesthetics
- isocarboxazid
- pargyline
- phenelzine
- potassium citrate
- potassium hydrogencarbonate
- rasagiline
- sodium acetate
- sodium bicarbonate
- sodium citrate
- sodium lactate
- tranylcypromine
Key clinical trials
- Effect of Systemic Inflammatory Index and Systemic Immune Inflammation Index on Ecchymosis, Bleeding and Edema
- Restrictive vs Liberal Intraoperative Fluid Strategy and Postoperative Outcomes After Elective Cesarean Section (NA)
- Oxymetazoline Drops for Acquired Blepharoptosis From Synkinesis (PHASE3)
- Changes of Ciprofol Dosage and Bispectral Index Required for Loss of Consciousness in Patients of Different Ages
- Study to Assess Safety and Efficacy of Fexofenadine Hydrochloride (HCL) + Pseudoephedrine HCL Fixed Dose Combination in Indian Male and Female Participants With Allergic Rhinitis (AR) Who Are 12 Years and Above (PHASE4)
- Laser Acupuncture for Otitis Media With Effusion in Children (NA)
- Use of Vasopressors in Hypotension Associated With Spinal Anaesthesia in Caesarean Sections (NA)
- Norepinephrine With Ephedrine Versus Norepinephrine Alone During Spinal Anesthesia for Cesarean Delivery (PHASE4)
Patents
| Patent | Expiry | Type |
|---|---|---|
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| FDA label | Mechanism, indications, dosing, boxed warnings, drug interactions |
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
| FDA Orange Book | Patents + exclusivity |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Akovaz CI brief — competitive landscape report
- Akovaz updates RSS · CI watch RSS