NCT06146491 is a Phase 4 clinical trial of Oral tablet and transdermal patch in Pain, Postoperative, sponsored by B.P. Koirala Institute of Health Sciences.

Who is sponsoring NCT06146491?

NCT06146491 is sponsored by B.P. Koirala Institute of Health Sciences.

What drugs are being tested in NCT06146491?

Interventions in NCT06146491: Oral tablet and transdermal patch.

What condition does NCT06146491 study?

NCT06146491 studies Pain, Postoperative.

Is NCT06146491 still recruiting?

NCT06146491 is currently status unknown. Last updated 24 November 2023.

Last reviewed 2023-11-24 · How we verify

NCT06146491

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

A COMPARISON OF TRANSDERMAL DICLOFENAC AND ORAL COMBINATION OF PARACETAMOL AND IBUPROFEN IN POSTOPERATIVE PAIN MANAGEMENT FOLLOWING SURGICAL EXTRACTION OF MANDIBULAR THIRD MOLAR- A RANDOMISD CONTROLLED TRIALS.

Status unknown Phase 4 Last updated 24 November 2023

What this trial tests

Phase 4 trial testing Oral tablet and transdermal patch in Pain, Postoperative in 108 participants. Status unknown.

Timeline

10 August 2023

Primary endpoint
15 January 2024

15 January 2024

Quick facts

Lead sponsor	B.P. Koirala Institute of Health Sciences
Phase	Phase 4
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	108
Start date	10 August 2023
Primary completion	15 January 2024
Estimated completion	15 January 2024
Sites	1 location across Nepal

Drugs / interventions tested

Oral tablet and transdermal patch — full drug profile →

Conditions studied

Pain, Postoperative — all drugs for Pain, Postoperative →

Sponsor

B.P. Koirala Institute of Health Sciences

Who can join

18 and older, any sex, with Pain, Postoperative. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This is comparative interventional study, will be conducted in patient indicated for surgical extraction of mandibular third molar at the Department of Oral and Maxillofacial surgery, College of Dental Surgery, BPKIHS, Nepal. Verbal and written will be taken . Participants meeting inclusion criteria will be included in the study and will be divided in to two groups, group A (Oral combination of paracetamol-500mg and ibuprofen -400mg) and group B ( Transdermal diclofenac patch-200mg) using computer generated randamization. Extraction will be carried out using standard protocol. Aformention drugs will given to participants accordingly for management of post operative pain.Tramadol will be given to each patient as rescue analgesics and allowed to have if pain score exceeds 7.post operative instruction will be given carefully. Rescue phone number will be provided in case of emergency. Telephonic interview will be performed at 12, 24 and 72 hours post operatively and pain score using numeric rating scale will be recorded.Any adverse effects of drugs will be recorded. The data collected will be entered in Microsoft excel sheet. It will then be transferred into SPSS (Statistical Package for Social Sciences) for statistical analysis.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Transdermal diclofenac versus oral paracetamol-ibuprofen combination for postoperative pain following surgical extraction of mandibular third molar: a randomized controlled trial.
Khanal N, Jaisani MR, Dongol A, Acharya P, et al · · 2025 · PMID 41377332 · DOI 10.1097/ms9.0000000000004076

Verify or expand the search:

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Other B.P. Koirala Institute of Health Sciences trials

Trials by the same sponsor.

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NCT07003581 — Cardiometabolic Risk Factors Associated With Multidrug-Resistant Tuberculosis · completed
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NCT06039475 — Risk Factors Associated With High Altitude Sickness: A Case-Control Study · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT06146491 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by B.P. Koirala Institute of Health Sciences
Last refreshed: 24 November 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06146491.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing