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Normal Saline (Placebo)
Normal saline is an inert isotonic solution that serves as a physiological control or placebo with no active pharmacological mechanism.
Normal saline is an inert isotonic solution that serves as a physiological control or placebo, providing no active therapeutic mechanism. Used for Placebo control in clinical trials.
At a glance
| Generic name | Normal Saline (Placebo) |
|---|---|
| Also known as | Normal saline, Instillation Normal saline after radical nephroureterectomy, Placebo, 0.9% Sodium Chloride, Normal Saline |
| Sponsor | Harbin Medical University |
| Modality | Small molecule |
| Phase | FDA-approved |
Mechanism of action
Normal saline (0.9% sodium chloride in water) is a sterile solution that matches the osmolarity and electrolyte composition of human blood plasma. It is used as a placebo comparator in clinical trials because it has no therapeutic mechanism of action and is well-tolerated, making it an appropriate control for blinded study designs.
Approved indications
- Placebo control in clinical trials
Common side effects
- Minimal adverse events expected (inert control)
Key clinical trials
- PRP Injection Into the Sacroiliac Joint After Ipsilateral THA: Effects on Early Recovery and Function (SIJ-THA Randomized Trial) (NA)
- Pulse Glucocorticoid Therapy in Patients With ST-Segment Elevation Myocardial Infarction (PHASE2)
- Magnesium Supplementation in Advanced Non-small Cell Lung Cancer (NSCLC) (PHASE2, PHASE3)
- Effects of Bronchial Segmental Endotoxin Instillation in Humans (PHASE2)
- Tirzepatide in MetALD (PHASE2)
- Thumb Base Osteoarthritis: Ultrasound-guided Platelet-rich Plasma Versus Placebo Injection (PHASE2)
- Safety Evaluation of PfSPZ Vaccine in Pregnant Women in Mali (MalVIP1) (PHASE1)
- Inflammatory Challenge in Human Aggression. (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Normal Saline (Placebo) CI brief — competitive landscape report
- Normal Saline (Placebo) updates RSS · CI watch RSS
- Harbin Medical University portfolio CI