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NCT06658795
Treating Loneliness In The Older Adult With Depression With tDCS
NA trial testing Transcranial direct current stimulation (tDCS) on the Left DLPFC in Major Depressive Disorder in 180 participants. Currently enrolling.
20 October 2026
Quick facts
| Lead sponsor | Guangzhou Psychiatric Hospital |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 180 |
| Start date | 29 October 2024 |
| Primary completion | 20 October 2026 |
| Estimated completion | 30 December 2026 |
| Sites | 1 location across China |
Drugs / interventions tested
- Transcranial direct current stimulation (tDCS) on the Left DLPFC
- Transcranial direct current stimulation (tDCS) on the right VLPFC
- Sham stimulation group
Conditions studied
- Major Depressive Disorder — all drugs for Major Depressive Disorder →
- Loneliness — all drugs for Loneliness →
Sponsor
Guangzhou Psychiatric Hospital
Who can join
Adults 60 to 80, any sex, with Major Depressive Disorder or Loneliness. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
High loneliness is prevalent among older adults and is a significant risk factor for major depression and low recovery rates in patients. Current interventions for loneliness are limited. Previous research has demonstrated a link between loneliness, negative social emotions, and reduced resting-state functional connectivity in the lateral prefrontal cortex (LPFC) and the default mode network (DMN). Transcranial direct current stimulation (tDCS) has shown promise in enhancing emotional regulation and connectivity, potentially alleviating loneliness in older adults with depression.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06658795
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Guangzhou Psychiatric Hospital trials
Trials by the same sponsor.
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- NCT04803071 — Omega-3 Unsaturated Fatty Acid Improves Cognitive Function in Patients With Depression · NA · unknown
- NCT04447430 — Light Therapy to Improve Symptoms in Pregnant Women With Major Depressive Disorder · NA · unknown
- NCT04124276 — Evaluation of Efficacy of Lycium Barbarum Polysaccharide in Patients With Major Depressive Disorder · NA · unknown
- NCT04032795 — Evaluation of Efficacy of Lycium Barbarum Polysaccharide in People With Subthreshold Depression · NA · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06658795 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Guangzhou Psychiatric Hospital
- Last refreshed: 26 October 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06658795.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing