NCT04032795

Evaluation of Efficacy of Lycium Barbarum Polysaccharide in People With Subthreshold Depression

Status unknown NA Last updated 19 November 2021

What this trial tests

NA trial testing Lycium barbarum polysaccharide in Subthreshold Depression in 172 participants. Status unknown.

Timeline

15 May 2019

Primary endpoint
30 December 2021

30 December 2021

Quick facts

Lead sponsor	Guangzhou Psychiatric Hospital
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	172
Start date	15 May 2019
Primary completion	30 December 2021
Estimated completion	30 December 2021
Sites	1 location across China

Drugs / interventions tested

• Lycium barbarum polysaccharide
• Placebo

Conditions studied

• Subthreshold Depression — all drugs for Subthreshold Depression →
• Depressive Symptoms — all drugs for Depressive Symptoms →
• Anxious Symptoms — all drugs for Anxious Symptoms →

Sponsor

Guangzhou Psychiatric Hospital

Who can join

Adults 12 to 18, any sex, with Subthreshold Depression or Depressive Symptoms. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Lycium barbarum, a traditional Chinese herbal medicine, is a commonly used herb in the traditional Chinese pharmacopoeia . Its main active ingredient, lycium barbarum polysaccharide (LBP), is reported to have neuroprotective effects. Animal studies suggested that LBP has neuroprotective effect on optic ganglion cells. In animal models of depression, LBP can improve depressive symptom by improving synaptic plasticity. However, its clinical effect remains to be studied. We will conduct a 6-week double-blind, randomized, placebo-con-trolled trial in people with subthreshold depression.The purpose of this clinical trial is to investigate the efficacy of LBP in people with subthreshold depression.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Efficacy of <i>Lycium barbarum</i> polysaccharide in adolescents with subthreshold depression: interim analysis of a randomized controlled study.
   Li X, Mo X, Liu T, Shao R, et al · · 2022 · cited 33× · PMID 34916444 · DOI 10.4103/1673-5374.330618
2. Effects of Lycium barbarum polysaccharide on cytokines in adolescents with subthreshold depression: a randomized controlled study.
   Li X, Liu T, Mo X, Wang R, et al · · 2024 · cited 8× · PMID 38227533 · DOI 10.4103/1673-5374.389360