Last reviewed · How we verify
NCT06252532
Causal Role of Top-Down Theta Oscillations in Prioritization
NA trial testing Direct cortical stimulation (DCS) Alpha in Working Memory in 50 participants. Enrolling by invitation.
31 January 2026
Quick facts
| Lead sponsor | University of North Carolina, Chapel Hill |
|---|---|
| Phase | NA |
| Status | ENROLLING BY INVITATION |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | basic science |
| Enrollment | 50 |
| Start date | 1 July 2024 |
| Primary completion | 31 January 2026 |
| Estimated completion | 31 January 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Direct cortical stimulation (DCS) Alpha
- Direct cortical stimulation (DCS) Theta
- Sham Direct cortical stimulation (DCS)
- Direct cortical stimulation (DCS) In-Phase Theta
- Direct cortical stimulation (DCS) Anti-Phase Theta
Conditions studied
- Working Memory — all drugs for Working Memory →
- Epilepsy — all drugs for Epilepsy →
Sponsor
University of North Carolina, Chapel Hill
Who can join
Adults 18 to 80, any sex, with Working Memory or Epilepsy. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Purpose: The purpose of this pilot study is to investigate the dynamics between theta and alpha oscillations in the control of working memory. These findings will be informative of what types of brain stimulation are most effective at modulating brain activity. Deep brain stimulation and transcranial magnetic stimulation are used for an increasing number of neurological and psychiatric disorders. Participants: Eligible participants are patients who have previously had electrodes implanted to monitor epilepsy (outside of research activity). 50 participants will be recruited, 25 participants for each phase of the study. Procedures (methods): The participants will perform a cognitive control task. During the task, rhythmic trains of direct cortical stimulation will be delivered to the frontal cortex alone or to the frontal and parietal cortex. Electrocorticography will be collected concurrent with stimulation.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT06252532
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Working Memory
Currently open trials in the same condition.
- NCT07319117 — Evaluation of the Impact of a Nutritional Formulation on Cognitive Performance Following Stress Exposure. · NA · recruiting
- NCT06918704 — BID WM Digital Intervention in Aging · NA · recruiting
- NCT05923606 — Modulation of Brain Oscillations Underlying Working Memory · NA · recruiting
- NCT05662280 — NIMH K23: Modulation of Frontoparietal Dynamics in Adolescent Working Memory Deficits · NA · active not recruiting
- NCT05399381 — Traveling-wave Transcranial Electric Stimulation · NA · active not recruiting
Other University of North Carolina, Chapel Hill trials
Trials by the same sponsor.
- NCT06841913 — Woodsmoke Exposure, Influenza Infection, and Nasal Immunity · Phase 4 · suspended
- NCT07383428 — The INICIO-Guatemala Study · NA · not yet recruiting
- NCT07528443 — Ultraprocessed Foods in Colombia · NA · not yet recruiting
- NCT07507370 — CARED : A Novel Rapid Treatment Paradigm for Depression · NA · not yet recruiting
- NCT07534254 — Piloting a Generative Artificial Intelligence Chatbot in a Mobile Weight Loss Program · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT06252532 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of North Carolina, Chapel Hill
- Last refreshed: 8 January 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT06252532.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing