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NCT05662280
NIMH K23: Modulation of Frontoparietal Dynamics in Adolescent Working Memory Deficits
NA trial testing Active Intermittent Theta Burst Stimulation in Working Memory in 40 participants. Participants enrolled and being followed up; not accepting new ones.
1 December 2026
Quick facts
| Lead sponsor | Bradley Hospital |
|---|---|
| Phase | NA |
| Status | Active, enrolled |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | double |
| Primary purpose | basic science |
| Enrollment | 40 |
| Start date | 1 December 2022 |
| Primary completion | 1 December 2026 |
| Estimated completion | 1 December 2026 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Active Intermittent Theta Burst Stimulation
- Sham Intermittent Theta Burst Stimulation
Conditions studied
- Working Memory — all drugs for Working Memory →
Sponsor
Bradley Hospital
Who can join
Adults 12 to 18, any sex, with Working Memory. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Working memory (WM) deficits are a transdiagnostic feature of adolescent psychopathology that substantially contribute to poor clinical and functional outcomes. This proposal will utilize a multimodal neuroscientific approach to investigate whether non-invasive brain stimulation can modulate the neural mechanisms underlying adolescent WM deficits. Directly in line with NIMH priorities, the researchers will identify the contributing roles of prefrontal and parietal regions in WM processes, as well as identify optimal targets and parameters for novel brain-based treatments in adolescent psychopathology. This study is funded by the NIMH-K23
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Dysfunctional oscillatory bursting patterns linked to working memory in adolescents with attention deficit hyperactivity disorder.
Kavanaugh BC, Vigne MM, Gamble I, Legere C, et al · · 2025 · PMID 41239129 · DOI 10.3758/s13415-025-01361-6
Verify or expand the search:
- PubMed search for NCT05662280
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Active Intermittent Theta Burst Stimulation
Trials testing the same drug.
- NCT07414147 — TMS for Improving Cognitive Function in Bipolar Disorder · NA · not yet recruiting
Other recruiting trials for Working Memory
Currently open trials in the same condition.
- NCT07319117 — Evaluation of the Impact of a Nutritional Formulation on Cognitive Performance Following Stress Exposure. · NA · recruiting
- NCT06918704 — BID WM Digital Intervention in Aging · NA · recruiting
- NCT05923606 — Modulation of Brain Oscillations Underlying Working Memory · NA · recruiting
- NCT05399381 — Traveling-wave Transcranial Electric Stimulation · NA · active not recruiting
- NCT03935646 — Acute Effects of Stimulant Medication in College Students With ADHD · Phase 2 · recruiting
Other Bradley Hospital trials
Trials by the same sponsor.
- NCT06549491 — A Sleep Intervention for Preschoolers in Foster Care · NA · not yet recruiting
- NCT06885047 — Culturally Centered CBT Protocol for Suicidal Behaviors Among Youth in Mexico City · NA · not yet recruiting
- NCT06934525 — Implementing Team-Based Treatment for Pediatric Anxiety in Community Mental Health Settings · NA · recruiting
- NCT07219810 — Accelerated iTBS Targeting of Working Memory Versus Inhibitory Control in Adolescent ADHD · NA · recruiting
- NCT07379853 — Interactive E-Learning for Therapist Training in Exposure Therapy · NA · enrolling by invitation
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT05662280 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Bradley Hospital
- Last refreshed: 9 September 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT05662280.
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