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NCT07507370: CARED
CARED : A Novel Rapid Treatment Paradigm for Depression
NA trial testing Intermittent Theta Burst Stimulation (iTBS) in Major Depressive Disorder in 30 participants. Not yet recruiting.
1 July 2028
Quick facts
| Lead sponsor | University of North Carolina, Chapel Hill |
|---|---|
| Phase | NA |
| Status | Not yet recruiting |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | treatment |
| Enrollment | 30 |
| Start date | 1 April 2026 |
| Primary completion | 1 July 2028 |
| Estimated completion | 1 July 2028 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Intermittent Theta Burst Stimulation (iTBS)
- Transcranial Alternating Current Stimulation (tACS)
- Psychotherapy
- Sham (Placebo) Transcranial Alternating Current Stimulation (tACS)
Conditions studied
- Major Depressive Disorder — all drugs for Major Depressive Disorder →
Sponsor
University of North Carolina, Chapel Hill
Who can join
Adults 18 to 70, any sex, with Major Depressive Disorder. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this study is to primarily assess the feasibility and secondarily assess the efficacy of a single session intervention (SSI) that combines non-invasive brain stimulation and psychotherapy for Major Depressive Disorder (MDD). investigators will recruit 30 people with MDD, with at least mild to moderate symptoms, who are resistant to typical treatments for Major Depressive Disorder. In this trial, participants will receive psychotherapy, Intermittent Theta Burst Stimulation Transcranial Magnetic Stimulation (iTBS), and either active or sham (placebo) Transcranial Alternating Current Stimulation (tACS).
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07507370
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Intermittent Theta Burst Stimulation (iTBS)
Trials testing the same drug.
- NCT05389644 — TMS as a Treatment for Apathy in Alzheimer's Disease · NA · terminated
- NCT05523817 — Targeting Specific Brain Networks to Treat Specific Symptoms in Depression · NA · recruiting
- NCT03984201 — Accelerated Theta Burst in Chronic Pain: A Biomarker Study · NA · withdrawn
- NCT05179785 — Examining the Effect of EEG-guided Theta Burst Stimulation in Bipolar Disorder · NA · completed
- NCT04999553 — Left vs. Right Non-Inferiority Trial · NA · unknown
Other recruiting trials for Major Depressive Disorder
Currently open trials in the same condition.
- NCT07219394 — Peer-Delivered Behavioral Activation in a CCBHC · NA · recruiting
- NCT06705478 — Pramipexole Versus Escitalopram to Treat Major Depressive Disorder (MDD) and Comorbid MDD With Mild Neurocognitive Disor · Phase 2 · recruiting
- NCT06749392 — An Individual-specific Synchrony Signature · NA · recruiting
- NCT07316803 — Group Intervention for Romantic Relationships in Young Adults With Severe Mental Illness · NA · recruiting
- NCT07242105 — Optimizing Brain Excitability in Depression · NA · recruiting
Other University of North Carolina, Chapel Hill trials
Trials by the same sponsor.
- NCT06841913 — Woodsmoke Exposure, Influenza Infection, and Nasal Immunity · Phase 4 · suspended
- NCT07383428 — The INICIO-Guatemala Study · NA · not yet recruiting
- NCT07528443 — Ultraprocessed Foods in Colombia · NA · not yet recruiting
- NCT07534254 — Piloting a Generative Artificial Intelligence Chatbot in a Mobile Weight Loss Program · NA · recruiting
- NCT07303062 — Adolescent Mental Health Parenting Program for Child-Adult Relationship Enhancement · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07507370 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of North Carolina, Chapel Hill
- Last refreshed: 2 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07507370.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing